Results: 130

Uso de posaconazol en niños: experiencia en un hospital pediátrico de alta complejidad

Arch. argent. pediatr; 116 (3), 2018
La información sobre el uso de posaconazol en niños es escasa. Se realizó este estudio descriptivo retrospectivo entre agosto de 2010 y marzo de 2017 para evaluar las características clínicas, microbiológicas y la evolución de los pacientes tratados con posaconazol. Se incluyeron 16 niños. Median...

Effectiveness and tolerability of direct-acting antivirals for chronic hepatitis C patients in a Southern state of Brazil

Braz. j. infect. dis; 22 (3), 2018
ABSTRACT Background This study aimed to evaluate the clinical effectiveness in terms of sustained virological response and tolerability of available second generation direct-acting antivirals in Brazilian patients. Methods This was a retrospective observational study conducted in six centers in Souther...

Avaliação de fatores prognósticos a curto prazo com o uso de ranibizumabe em pacientes com edema macular diabético

Rev. bras. oftalmol; 77 (3), 2018
Resumo Objetivo: Investigar fatores prognósticos a curto prazo em pacientes portadores de edema macular diabético (EMD) tratados com injeções intravítreas (IV) de ranibizumabe (RZB). Métodos: Estudo descritivo transversal, retrospectivo, analisou-se 41 prontuários de uma clínica privada na cida...

In vitro efficacy of essential oils with different concentrations of 1, 8-cineole against Rhipicephalus (Boophilus) microplus

Abstract The aim of this study was to evaluate the acaricidal activity of essential oils from three species of plants with intermediary concentrations of 1,8-cineole against the tick species Rhipicephalus (Boophilus) microplus. For this purpose, five serial concentrations (100.0, 50.0, 25.0, 12.5, 6.2 m...

Pouteria torta: a native species of the Brazilian Cerrado as a bioindicator of glyphosate action

Braz. j. biol; 78 (2), 2018
Abstract In Brazil, the expansion of agricultural activity and the associated indiscriminate use of herbicides such as glyphosate is directly related to the loss of biodiversity in the Cerrado. The identification of plant species as bioindicators of herbicide action, especially species native to the area...

Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review

Abstract Chagas disease is a protozoan infection that was identified over a century ago. No drugs are available to treat the indeterminate and determinate chronic phases of the disease. Success of a drug design is dependent on correct biological evaluation. Concerning new drug designs for Chagas disease,...

Evaluation of in vitro anti-Trypanosoma cruzi activity of medications benznidazole, amiodarone hydrochloride, and their combination

Abstract INTRODUCTION: Approximately seven to eight million people worldwide have Chagas disease. In Brazil, benznidazole is the most commonly used active drug against Trypanosoma cruzi; however, its efficacy is limited, and side effects are frequent. Recent studies suggest that amiodarone may be benefi...

Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections

Braz. j. infect. dis; 22 (1), 2018
ABSTRACT Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid. In the present study, fluconazole levels were determined in 15 patients, 14 of whom had AI...

El control intensivo de la presión arterial en pacientes sin diabetes con enfermedad renal crónica no reduciría la progresión de la enfermedad renal
Intensive blood pressure control in nondiabetic patients with chronic kidney disease would not prevent kidney disease progression

Anethole reduces oxidative stress and improves in vitro survival and activation of primordial follicles

Braz. j. med. biol. res; 51 (8), 2018
Primordial follicles, the main source of oocytes in the ovary, are essential for the maintenance of fertility throughout the reproductive lifespan. To the best of our knowledge, there are no reports describing the effect of anethole on this important ovarian follicle population. The aim of the study was ...