Abstract The present study was aimed at conducting phytochemical analysis and evaluating the in vitro antifungal and antioxidant activities of the essential oil obtained from the fruits of J. oxycedrus L. Hydro-distillation was used to extract the essential oil from the fruits of Juniper oxycedrus. The ...
Antioxidantes/farmacología,
Aceites Volátiles/análisis,
Juniperus/efectos adversos,
Marruecos/etnología,
Frutas/clasificación,
Antifúngicos/farmacología,
Fitoquímicos/análisis,
Cromatografía de Gases/métodos,
Espectrometría de Masas/métodos,
d0000772220,
Pruebas de Sensibilidad Microbiana/métodos,
Técnicas In Vitro/métodos
Abstract Biological activity of boron-containing compounds (BCCs) has been well-known. Growing interest and numerous applications for BCCs have been reported. Boron and boron-containing acids show low acute toxicity in mammals but data on halogenated boroxine (HB) - dipotassium-trioxohydroxytetrafluorotr...
Desarrollo de Medicamentos/instrumentación,
Boro/agonistas,
Pruebas de Toxicidad Aguda/instrumentación,
Antioxidantes/farmacología,
d0099340,
Productos Biológicos/efectos adversos,
Técnicas In Vitro/métodos,
d0001430,
d0079280,
d0207140,
ddcs0516950
Abstract Donepezil-HCl is a member of the acetylcholinesterase inhibitors that is indicated for the symptomatic treatment of Alzheimer’s disease (AD) and has many side effects. In this study, to reduce the side effects of Donepezil-HCl and increase the penetration of the drug through the blood-brain ba...
Abstract Present study analysed the therapeutic potential of traditionally acclaimed medicinal herb Nanorrhinum ramosissimum, using plant parts extracted with different solvents (10 mg/mL). Shoot extracts exhibited comparatively better antimicrobial properties, in comparison to root extracts. Total pheno...
Abstract Voriconazole increases tacrolimus blood concentration significantly when coadministrated. The recommendation of reducing tacrolimus to 1/3 in voriconazole package insert seems not to be satisfactory in clinical practice. In vitro studies demonstrated that the magnitude of inhibition depends on t...
Abstract Development of ceftriaxone loaded nanostructured lipid carriers to increase permeability of ceftriaxone across uninflamed meninges after parenteral administration. Lipids were selected by theoretical and experimental techniques and optimization of NLCs done by response surface methodology using ...
Triaje/clasificación,
Lípidos/análisis,
Ceftriaxona/agonistas,
Difracción de Rayos X/instrumentación,
Infecciones del Sistema Nervioso Central/patología,
d0045260,
ddcs0502240,
d0043640,
d0084030,
d0129950,
Técnicas In Vitro/métodos
Abstract Treatment with plant is considered an effective option against increased antibiotic resistance. In this study antibiofilm activity of methanol (CH3OH), chloroform (CHCl3), ethyl acetate (EtOAc) and water (H2O) extracts of Hypericum atomarium Boiss. which is member of Hypericum genus was evaluate...
Abstract Chagas disease is a neglected parasitic disease caused by Trypanosoma cruzi, whose treatment has remained unsatisfactory for over 50 years, given that it is limited to two drugs. Benznidazole (BZN) is an efficient antichagasic drug used as the first choice, although its poor water-solubility, i...
Trypanosoma cruzi/aislamiento & purificación,
Enfermedades Desatendidas/clasificación,
Análisis Espectral/instrumentación,
Difracción de Rayos X/instrumentación,
Enfermedad de Chagas/patología,
Enfermedades Parasitarias/patología,
Esguinces y Distensiones/clasificación,
Espectroscopía Infrarroja por Transformada de Fourier/métodos,
Preparaciones Farmacéuticas/análisis,
d0129950,
Termogravimetría/métodos,
Técnicas In Vitro/métodos
Abstract The aim of this study was to compare the dissolution properties of ibuprofen solid oral dosage forms commercially available in Bosnia and Herzegovina and to estimate the influence of dissolution medium composition on the drug release. Eight products (A-H) were subjected to in vitro dissolution t...
The purpose of this study was to propose a bicompartmental nonlinear model and to identify the best-performing model between the proposed model and the bicompartmental logistic (BL) mode regarding the quality of fit to the curve of cumulative gas production (CGP) using corn silage, sunflower, and their m...
