Results: 205

The effect of testosterone replacement on intramedullary, inguinal and visceral fat in ovariectomized rats

Abstract Objective The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma....

Impacto da orquiectomia e terapia de reposição hormonal com cipionato de testosterona no estresse oxidativo e função secretora das glândulas salivares de ratos Wistar

Apesar da comprovada capacidade da testosterona (T) em modular o estresse oxidativo de forma tecido-específica, pouco se sabe se as glândulas salivares estão sujeitas a essa modulação. O objetivo foi investigar os efeitos da orquiectomia (OQX) e da terapiadereposiçãohormonal(TRH) comTnoestresse ox...

Testosterone antagonizes paraquat-induced cardiomyocyte senescence via the mIGF-1/SIRT1 signaling pathway

Braz. j. med. biol. res; 53 (10), 2020
Testosterone has been demonstrated to antagonize doxorubicin-induced cardiomyocyte senescence. However, whether testosterone prevents the paraquat-induced cardiomyocyte senescence is largely unknown. The detection of SA-β-gal activity was performed using senescence β-gal staining kit and the re...

Does a bilateral polypropylene mesh alter the duct deferens morphology, testicular size and testosterone levels? Experimental study in rats

Acta cir. bras; 35 (2), 2020
Abstract Purpose To evaluate the effect of a PP mesh on duct deferens morphology, testicular size and testosterone levels. Methods Forty adult male rats were distributed into groups: 1) no surgery; 2) inguinotomy; 3) mesh placed on the duct deferens; and 4) mesh placed on the spermatic funiculus. Aft...

Prepubertal gynecomastia: a rare manifestation of myotonic dystrophy type 1

ABSTRACT Objective: To present a case of bilateral gynecomastia in a prepubertal boy with autism spectrum disorder, diagnosed with myotonic dystrophy type 1. Case description: A 12-year-old boy with autism spectrum disorder presented at a follow-up visit with bilateral breast growth. There was a fami...

Salud ósea en personas transgénero
Bone health in transgender subjects

Actual. osteol; 16 (3), 2020
Una persona transgénero es aquella en la cual el género autopercibido difiere del asignado al nacer, mientras que el término cisgénero es utilizado en aquellos individuos no trans. El tratamiento hormonal cruzado (THC) constituye una opción para lograr caracteres sexuales secundarios deseados. Es co...

Hormonas sexuales en la enfermedad crítica
Sexual hormones in critical disease

Cambios rev. méd; 18 (2), 2019
INTRODUCCIÓN. En el paciente crítico ha existido un conglomerado de situaciones dadas por alteración de las hormonas acorde al comportamiento del eje hipotalámi-co-hipofisario- gonadal, entender su rol es fundamental. OBJETIVO. Describir las alteraciones de las hormonas sexuales en el paciente críti...

Intervalo de referencia de testosterona en hombres adultos jóvenes del municipio Plaza de la Revolución

Rev. cuba. endocrinol; 30 (3), 2019
RESUMEN Introducción: El hipogonadismo masculino puede provocar una reducción importante de la calidad de vida. La determinación de testosterona total constituye la opción inicial para el diagnóstico bioquímico del hipogonadismo. Objetivo: Determinar el intervalo de referencia de testosterona to...

Effect of testosterone on proliferation markers and apoptosis in breasts of ovariectomized rats

Abstract Objective To investigate the action of testosterone (T), isolated or associated with estradiol benzoate (EB), on the proliferation markers and apoptosis of breasts of ovariectomized rats. Methods A total of 48 castrated female Wistar rats were divided into 6 groups, and each of them were sub...