Background: Cinnamomum longepaniculatum is an important commercial crop and the main source of volatile terpenoids. The biosynthesis of key bioactive metabolites of C. longepaniculatum is not well understood because of the lack of available genomic and transcriptomic information. To address this issue, w...
No Brasil, organofosforados (OP) e piretróides (PI) foram usados para o controle de larvas e adultos de A. aegypti, respectivamente, desde 1967 e 2000. O uso frequente destes produtos selecionou populações resistentes do vetor. Optou-se então por usar o OP fosforoditioato malathion no controle dos ad...
Different pathways act synergistically to participate in many biological processes. Thus, the purpose of our study was to extract dysregulated pathways to investigate the pathogenesis of colorectal cancer (CRC) based on the functional dependency among pathways. Protein-protein interaction (PPI) informati...
Adenoma/genética,
Adenoma/metabolismo,
Área Bajo la Curva,
Biomarcadores de Tumor/genética,
Estudios de Casos y Controles,
Neoplasias Colorrectales/genética,
Neoplasias Colorrectales/metabolismo,
Perfilación de la Expresión Génica/métodos,
Regulación de la Expresión Génica,
Análisis de Componente Principal,
Análisis por Matrices de Proteínas,
Mapas de Interacción de Proteínas/genética,
Empalme del ARN,
Valores de Referencia,
Transducción de Señal,
Transcriptoma
Background: Cutaneous melanoma (CM) is the most aggressive subtype of skin cancer, with increasing incidence over the past several decades. DNA methylation is a key element of several biological processes such as genomic imprinting, cell differentiation and senescence, and deregulation of this mechanism ...
BACKGROUND: Earthworms are sensitive to toxic chemicals present in the soil and so are useful indicator organisms for soil health. Eisenia fetida are commonly used in ecotoxicological studies; therefore the assembly of a baseline transcriptome is important for subsequent analyses exploring the impact of ...
Ecotoxicología,
Perfilación de la Expresión Génica/métodos,
Oligoquetos/genética,
Transcriptoma,
Oligoquetos/efectos de los fármacos,
Análisis de Secuencia de ARN/métodos,
Contaminantes del Suelo/toxicidad,
Toxicogenética/métodos,
Exposición a Riesgos Ambientales,
Ontología de Genes,
Programas Informáticos
The insect integument, formed by the cuticle and the underlying epidermis, is essential for insect fitness, regulation of lipid biosynthesis and storage, insect growth and feeding, together with development progress. Its participation in insecticide resistance has also been outlined. Triatoma infestans K...
Dilated cardiomyopathy (DCM) is characterized by ventricular dilatation, and it is a common cause of heart failure and cardiac transplantation. This study aimed to explore potential DCM-related genes and their underlying regulatory mechanism using methods of bioinformatics. The gene expression profiles o...
Cardiomiopatía Dilatada/genética,
Biología Computacional/métodos,
Regulación hacia Abajo,
Perfilación de la Expresión Génica/métodos,
MicroARNs,
Receptores Androgénicos/genética,
Valores de Referencia,
Transducción de Señal/genética,
Factores de Transcripción/genética,
Transcriptoma,
Regulación hacia Arriba
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the year...
Trastornos Respiratorios/genética,
Sepsis/complicaciones,
Sepsis/genética,
Estudios de Asociación Genética,
Transcriptoma,
Ciclo Celular/genética,
Bases de Datos Genéticas,
Regulación hacia Abajo,
Perfilación de la Expresión Génica,
Marcación de Gen,
Mapas de Interacción de Proteínas,
Factores de Transcripción,
Regulación hacia Arriba
BACKGROUND: Changed temperature not only threaten agricultural production, but they also affect individual biological behavior, population and community of many insects, and consequently reduce the stability of our ecosystem. Insect's ability to respond to temperature stress evolved through a complex ada...
Respuesta al Choque por Frío/genética,
Escarabajos/genética,
Respuesta al Choque Térmico/genética,
Secuenciación de Nucleótidos de Alto Rendimiento/métodos,
Transcriptoma,
Escarabajos/clasificación,
Escarabajos/enzimología,
Perfilación de la Expresión Génica/métodos,
Genes de Insecto/fisiología,
Análisis de Secuencia de ADN/métodos,
Estrés Fisiológico/genética,
Frío,
Cartilla de ADN,
Biblioteca de Genes,
Ontología de Genes,
Calor,
Reacción en Cadena en Tiempo Real de la Polimerasa
BACKGROUND: In the recent studies, it is suggested that the analysis of transcriptomic change of functional modules instead of individual genes would be more effective for system-wide identification of cellular functions. This could also provide a new possibility for the better understanding of differenc...
