ABSTRACT Mansoa hirsuta (Bignoniaceae) is a native plant from caatinga in Brazilian semiarid. This plant has been locally used as antimicrobial and hypoglycemiant agents, but their action mechanisms and toxicity remain largely unknown. Therefore, we evaluated the composition and antioxidant, cytoprotecti...
Antioxidantes/aislamiento & purificación,
Antioxidantes/farmacología,
Bignoniaceae/química,
Brasil,
Supervivencia Celular/efectos de los fármacos,
Células Cultivadas,
Cricetinae,
Citoprotección,
Etanol/química,
Fibroblastos/efectos de los fármacos,
Hipoglucemiantes/aislamiento & purificación,
Hipoglucemiantes/farmacología,
Cebollas/efectos de los fármacos,
Extractos Vegetales/farmacología,
Hojas de la Planta/química,
Valores de Referencia,
Reproducibilidad de los Resultados,
Triterpenos/química,
alfa-Amilasas/química
ABSTRACT In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activit...
Antituberculosos/química,
Antituberculosos/farmacología,
Recuento de Colonia Microbiana,
Etnobotánica,
Formazáns,
México,
Pruebas de Sensibilidad Microbiana,
Mycobacterium tuberculosis/efectos de los fármacos,
Extractos Vegetales/química,
Extractos Vegetales/farmacología,
Plantas Medicinales/química,
Reproducibilidad de los Resultados,
Sales de Tetrazolio
SILVA, VICTOR D A;
CUEVAS, CARLOS;
MUÑOZ, PATRICIA;
VILLA, MONICA;
AHUMADA-CASTRO, ULISES;
HUENCHUGUALA, SANDRO;
SANTOS, CLEONICE C DOS;
ARAUJO, FILLIPE M DE;
FERREIRA, RAFAEL S;
SILVA, VANESSA B DA;
SILVA, JULIANA H C E;
SOARES, ÉRICA N;
VELOZO, EUDES S;
SEGURA-AGUILAR, JUAN;
COSTA, SILVIA L.
ABSTRACT Prosopis juliflora is a shrub that has been used to feed animals and humans. However, a synergistic action of piperidine alkaloids has been suggested to be responsible for neurotoxic damage observed in animals. We investigated the involvement of programmed cell death (PCD) and autophagy on the m...
Adenosina Trifosfato/análisis,
Alcaloides/aislamiento & purificación,
Alcaloides/toxicidad,
Autofagia/efectos de los fármacos,
Autofagia/fisiología,
Muerte Celular/efectos de los fármacos,
Muerte Celular/fisiología,
Supervivencia Celular/efectos de los fármacos,
Células Cultivadas,
Potencial de la Membrana Mitocondrial/efectos de los fármacos,
Potencial de la Membrana Mitocondrial/fisiología,
Neuroglía/efectos de los fármacos,
Neuroglía/fisiología,
Piperidinas/aislamiento & purificación,
Piperidinas/toxicidad,
Extractos Vegetales/toxicidad,
Prosopis/química,
Ratas Wistar,
Factores de Tiempo
ABSTRACT Bauhinia holophylla, commonly known as "cow's hoof", is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes w...
Bauhinia/química,
Glucemia/análisis,
Glucemia/efectos de los fármacos,
Peso Corporal,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Ingestión de Líquidos,
Ingestión de Alimentos,
Prueba de Tolerancia a la Glucosa,
Hipoglucemiantes/farmacología,
Hipoglucemiantes/uso terapéutico,
Extractos Vegetales/farmacología,
Extractos Vegetales/uso terapéutico,
Hojas de la Planta/química,
Ratas Wistar,
Reproducibilidad de los Resultados,
Estreptozocina,
Factores de Tiempo,
Resultado del Tratamiento
Abstract Purpose: To measure the tissue sulfomucin and sialomucin content of the colon mucosa without fecal flow, subjected to intervention with curcumin, and the influence of the concentration used and the intervention time. Methods: Thirty-six rats were subjected to proximal right colostomy and dis...
Colon/química,
Colon/efectos de los fármacos,
Mucosa Intestinal/química,
Mucosa Intestinal/efectos de los fármacos,
Mucinas/análisis,
Extractos Vegetales/administración & dosificación,
Colitis/tratamiento farmacológico,
Colitis/patología,
Colon/patología,
Colostomía,
Curcuma,
Enema/métodos,
Heces,
Tránsito Gastrointestinal/efectos de los fármacos,
Procesamiento de Imagen Asistido por Computador,
Mucosa Intestinal/patología,
Mucinas/efectos de los fármacos,
Aceites de Plantas/administración & dosificación,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Sialomucinas/efectos de los fármacos,
Factores de Tiempo
Abstract Identifying new chemotherapeutic agents with fewer side effects is a major concern for scientists today. Thymus caramanicus Jalas (Lamiaceae family) is one of the species of Thymus that grows wild in different regions of Iran. Traditionally, leaves of this plant are used in the treatment of diab...
ABSTRACT INTRODUCTION: Cutaneous leishmaniasis (CL) is a tropical disease that affects millions of individuals worldwide. The current drugs for CL may be effective but have serious side effects; hence, alternatives are urgently needed. Although plant-derived materials are used for the treatment of vari...
Antiprotozoarios/farmacología,
Antiprotozoarios/uso terapéutico,
Artemisia annua/química,
Cricetinae,
Leishmania/efectos de los fármacos,
Leishmaniasis Cutánea/tratamiento farmacológico,
Pruebas de Sensibilidad Parasitaria,
Extractos Vegetales/farmacología,
Extractos Vegetales/uso terapéutico,
Hojas de la Planta/química,
Resultado del Tratamiento
Abstract: INTRODUCTION: The activity of garlic oil extract against Schistosoma japonicum cercariae was evaluated. METHODS: The in vitro and in vivo cercaricidal activities against S. japonicum larvae were determined. RESULTS: Exposure to ≥ 10-6 (v/v) garlic emulsions for 30 min led to 100% cer...
Abstract Purpose: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with wild plum (Ximenia americana) essential oil-based ointment in rats. Methods: Sixty rats were submitted to two cutaneous wounds in the thoracic region, on the right and left antimeres. Thereon...
