OBJECTIVES: This study aimed to evaluate several methods to estimate glucose consumption in the male Wister rat brain as measured by PET. METHODS: Fourteen male Wistar normoglycemic rats were studied. The input function consisted of seventeen blood samples drawn manually from the femoral artery. Glucose...
The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control group included 86 patients with uterine septum who had normal endometrium veri...
Western Blotting,
Estudios de Casos y Controles,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Ratas Wistar,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Índice de Severidad de la Enfermedad,
Transducción de Señal,
Proteínas Smad/genética,
Proteínas Smad/metabolismo,
Adherencias Tisulares/metabolismo,
Adherencias Tisulares/patología,
Factor de Crecimiento Transformador beta1/genética,
Factor de Crecimiento Transformador beta1/metabolismo,
Enfermedades Uterinas/metabolismo,
Enfermedades Uterinas/patología,
Receptor 2 de Factores de Crecimiento Endotelial Vascular/genética,
Receptor 2 de Factores de Crecimiento Endotelial Vascular/metabolismo
The objective was to study the effect of mechanical intestinal obstruction in rats on the phenotype of interstitial cells of Cajal (ICC). Healthy Wistar rats were randomly divided into sham-operation group (C), one day obstruction group (M1), two days obstruction group (M2), and three days obstruction gr...
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Células Intersticiales de Cajal/metabolismo,
Células Intersticiales de Cajal/patología,
Obstrucción Intestinal/metabolismo,
Obstrucción Intestinal/patología,
Fenotipo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
ARN Mensajero/metabolismo,
Ratas Wistar,
Factor de Células Madre/metabolismo
The effect of a short-term creatine supplementation on hindlimb suspension (HS)-induced muscle atrophy was investigated. Creatine monohydrate (5 g/kg b.w. per day) or placebo, divided in 2 daily doses, was given by oral gavage for 5 days. Rats were maintained in HS with dietary supplementation concomitan...
Narmada, Ida Bagus;
Laksono, Valerian;
Nugraha, Alexander Patera;
Ernawati, Diah Savitri;
Winias, Saka;
Prahasanti, Chiquita;
Dinaryanti, Aristika;
Susilowati, Helen;
Hendrianto, Eryk;
Ihsan, Igo Syaiful;
Rantam, Fedik Abdul.
Abstract Objective: To investigate the regeneration of rat's salivary gland diabetic defect after intraglandular transplantation of Human Dental Pulp Stem Cells (HDPSCs) on acinar cell vacuolization and Interleukin-10 (IL-10). Material and Methods: HDPSCs isolated from the dental pulp of first premolar...
Células Madre,
Inmunohistoquímica/instrumentación,
Ratas Wistar,
Estadísticas no Paramétricas,
Células Madre Totipotentes,
Interleucina-10,
Células Acinares,
Diabetes Mellitus,
Glándulas Salivales,
Pulpa Dental,
Indonesia
Abstract Colchicine is widely used in the treatment of several inflammatory diseases due to its anti-inflammatory effect, but effects on bone metabolism are unclear. The aim of this study was to evaluate the effects of systemically-administered colchicine on healthy periodontium and experimentally-induce...
Pérdida de Hueso Alveolar/tratamiento farmacológico,
Pérdida de Hueso Alveolar/patología,
Antiinflamatorios/farmacología,
Antiinflamatorios/uso terapéutico,
Colchicina/farmacología,
Colchicina/uso terapéutico,
Inmunohistoquímica,
Ligadura,
Metaloproteinasa 1 de la Matriz/análisis,
Osteoblastos/efectos de los fármacos,
Osteoclastos/efectos de los fármacos,
Periodontitis/tratamiento farmacológico,
Periodontitis/etiología,
Periodontitis/patología,
Ratas Wistar,
Reproducibilidad de los Resultados,
Fosfatasa Ácida Tartratorresistente/análisis,
Factores de Tiempo,
Resultado del Tratamiento,
Moduladores de Tubulina/farmacología
Abstract Purpose: To characterize qualitatively and quantitatively the absorption of metronidazole solution, in greater concentrations and for longer periods, when applied topically to an experimental open skin wound model. Methods: An open skin wound, 2 cm in diameter and total skin thickness was prep...
Abstract Purpose: To evaluate the effects of food restriction on fracture healing in growing rats. Methods: Sixty-eight male Wistar rats were assigned to two groups: (1) Control and (2) Dietary restriction. After weaning the dietary restricted animals were fed ad libitum for 42 days with 50% of the s...
Densidad Ósea/fisiología,
Callo Óseo/fisiología,
Fracturas del Fémur/diagnóstico por imagen,
Fracturas del Fémur/fisiopatología,
Fijación Intramedular de Fracturas,
Curación de Fractura/fisiología,
Fracturas Cerradas/diagnóstico por imagen,
Fracturas Cerradas/fisiopatología,
Desnutrición,
Osteoporosis/prevención & control,
Ratas Wistar
Abstract Purpose: To compare four types of mesh regarding visceral adhesions, inflammatory response and incorporation. Methods: Sixty Wistar rats were divided into four groups, with different meshes implanted intraperitoneally: polytetrafluoroethylene (ePTFE group); polypropylene with polydioxanone and...
Pared Abdominal,
Celulosa Oxidada/efectos adversos,
Hernia Incisional/cirugía,
Inflamación/patología,
Ensayo de Materiales,
Polipropilenos/efectos adversos,
Politetrafluoroetileno/efectos adversos,
Complicaciones Posoperatorias/prevención & control,
Prótesis e Implantes/efectos adversos,
Ratas Wistar,
Siliconas/efectos adversos,
Estadísticas no Paramétricas,
Mallas Quirúrgicas/efectos adversos,
Mallas Quirúrgicas/normas,
Adherencias Tisulares/patología,
Adherencias Tisulares/prevención & control,
Vísceras/fisiología
Abstract Purpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversib...
Compuestos de Benzalconio/farmacología,
Peso Corporal/efectos de los fármacos,
Toxinas Botulínicas/farmacología,
Desnervación/métodos,
Modelos Animales de Enfermedad,
Íleon/inervación,
Íleon/patología,
Yeyuno/inervación,
Debilidad Muscular/patología,
Ratas Wistar,
Síndrome del Intestino Corto/patología,
Síndrome del Intestino Corto/cirugía
