Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The solution of the SARS-CoV-2 Mpro structure allowed the investigation of potential inhibitors. This work aims to provide first evidences of the applic...
Abstract Objective: To evaluate the influence of cavosurface vestibular bevel (CSVB) application on the clinical success (CS) of class IV restorations of traumatized permanent teeth, the influence of the number of fracture angles and dental trauma recurrence (DTR) on the restorations retention rate (RRR...
Abstract Objective: To determine the prevalence of dental fluorosis in a population not exposed to fluoridated water and to evaluate the effect of the sampling technique on this measurement. Material and Methods: This observational, cross-sectional and quantitative study was conducted in the city of Ma...
Abastecimiento de Agua,
Fluoruración,
Encuestas y Cuestionarios,
Dentífricos/química,
Fluorosis Dental,
Estudios Epidemiológicos,
Estudios Transversales/métodos,
Prevalencia,
Diente,
Distribución de Chi-Cuadrado,
Brasil/epidemiología
BACKGROUND: The pellicle, the acellular organic material deposited on the surface of tooth enamel, has been thought to be derived from saliva. In this study, protein compositions of the pellicle, gingival crevicular fluid, and saliva collected from healthy adults were compared to elucidate the origin of ...
BACKGROUND: The intracellular concentration of heavy-metal cations, such as copper, nickel, and zinc is pivotal for the mycobacterial response to the hostile environment inside macrophages. To date, copper transport mediated by P-type ATPases across the mycobacterial plasma membrane has not been sufficie...
Methylophiopogonanone A (MO-A), a homoisoflavonoid extracted from Ophiopogon japonicus, has been shown to attenuate myocardial apoptosis and improve cerebral ischemia/reperfusion injury. However, the hypolipidemic effects remain unknown. This study was performed to investigate a potential hypolipidemic e...
Benzodioxoles/aislamiento & purificación,
Benzodioxoles/farmacología,
Western Blotting,
Dieta Alta en Grasa,
Modelos Animales de Enfermedad,
Heces/química,
Hiperlipidemias/metabolismo,
Hiperlipidemias/prevención & control,
Isoflavonas/aislamiento & purificación,
Isoflavonas/farmacología,
Metabolismo de los Lípidos,
Lípidos/análisis,
Ophiopogon/química,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa
The central nervous system shows limited regenerative capacity after injury. Spinal cord injury (SCI) is a devastating traumatic injury resulting in loss of sensory, motor, and autonomic function distal from the level of injury. An appropriate combination of biomaterials and bioactive substances is curre...
Sistema Nervioso Central/efectos de los fármacos,
Modelos Animales de Enfermedad,
Ensayo de Materiales,
Microfibrillas/química,
Microscopía Electrónica de Rastreo,
Copolímero de Ácido Poliláctico-Ácido Poliglicólico/química,
Ratas Wistar,
Traumatismos de la Médula Espinal/terapia,
Ingeniería de Tejidos/métodos,
Andamios del Tejido,
Ácido Valproico/administración & dosificación
Abstract Although dental implants and bone regenerative procedures are important approaches for the reestablishment of esthetics and function in young patients with a history of generalized aggressive periodontitis (GAP), no predictable outcomes have been reported, and the host osteo-immunoinflammatory r...
Periodontitis Agresiva/genética,
Periodontitis Agresiva/metabolismo,
Proceso Alveolar/química,
Biomarcadores,
Colágeno Tipo I/análisis,
Colágeno Tipo I/genética,
Estudios Transversales,
Expresión Génica,
Sialoproteína de Unión a Integrina/análisis,
Sialoproteína de Unión a Integrina/genética,
Osteocalcina/análisis,
Osteocalcina/genética,
Osteoprotegerina/análisis,
Osteoprotegerina/genética,
Ligando RANK/análisis,
Ligando RANK/genética,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Valores de Referencia,
Método Simple Ciego,
Estadísticas no Paramétricas,
Factor de Crecimiento Transformador beta/análisis,
Factor de Crecimiento Transformador beta/genética,
Factor de Necrosis Tumoral alfa/análisis,
Factor de Necrosis Tumoral alfa/genética
Abstract The objective of this study was to evaluate the influence of hydrofluoric acid (HF) concentration, etching time, and application of phosphoric acid (PA) followed by neutralization with sodium bicarbonate on the bond strength between a feldspar ceramic and resin cement. Thus, 80 blocks (10 x 12 x...
Silicatos de Aluminio/química,
Análisis de Varianza,
Recubrimiento Dental Adhesivo/métodos,
Porcelana Dental/química,
Ácido Fluorhídrico/química,
Ensayo de Materiales,
Metacrilatos/química,
Microscopía Electrónica de Rastreo,
Ácidos Fosfóricos/química,
Compuestos de Potasio/química,
Valores de Referencia,
Reproducibilidad de los Resultados,
Cementos de Resina/química,
Resistencia al Corte/efectos de los fármacos,
Silanos/química,
Propiedades de Superficie,
Factores de Tiempo
Abstract This study analyzed the effect of prior application of copaiba oil (CO) emulsions as a dentin cleaning substance on microleakage and microtensile adhesive strength. Twenty-five premolars and sixty-four molars were used for microleakage and microtensile assays. For the microleakage assays, specim...
Análisis de Varianza,
Clorhexidina/química,
Resinas Compuestas/química,
Recubrimiento Dental Adhesivo/métodos,
Cementos Dentales/química,
Filtración Dental,
Dentina/química,
Dentina/efectos de los fármacos,
Recubrimientos Dentinarios/química,
Emulsiones/química,
Fabaceae/química,
Ensayo de Materiales,
Aceites de Plantas/química,
Reproducibilidad de los Resultados,
Cementos de Resina/química,
Estadísticas no Paramétricas,
Propiedades de Superficie,
Resistencia a la Tracción
