El análisis secuencial de ensayos clínicos permite el monitoreo continuo de los datos emergentes para el investigador, así como una mayor seguridad para evitar someter a los participantes a una terapia inferior o fútil en términos de eficacia o seguridad, antes que esta sea evidente, mientras se con...
ABSTRACT The World Health Organization (WHO) was informed on December 2019 about a coronavirus pneumonia outbreak in Wuhan, Hubei province (China). Subsequently, on March 12, 2020, 125,048 cases and 4,614 deaths were reported. Coronavirus is an enveloped RNA virus, from the genus Betacoronavirus, that is...
ABSTRACT OBJECTIVE To identify and evaluate the effects of community-based interventions on the sedentary behavior (SB) of Latin American children and adolescents. METHODS A systematic review on community-based trials to reduce and/or control SB in Latin American countries (Prospero: CRD42017072157)....
ABSTRACT Objective: To perform a systematic review of literature data on gut microbiota and the efficacy of probiotics for the treatment of constipation in children and adolescents. Data source: The research was performed in the PubMed, the Scientific Electronic Library Online (SciELO) and the Latin ...
Dolor Abdominal/inducido químicamente,
Dolor Abdominal/epidemiología,
Ensayos Clínicos como Asunto,
Estreñimiento/microbiología,
Estreñimiento/terapia,
Suplementos Dietéticos/efectos adversos,
Heces/microbiología,
Flatulencia/inducido químicamente,
Flatulencia/epidemiología,
Microbioma Gastrointestinal/efectos de los fármacos,
Probióticos/administración & dosificación,
Probióticos/efectos adversos,
Probióticos/uso terapéutico
O objetivo deste estudo foi realizar o levantamento bibliográfico de artigos científicos e ensaios clínicos sobre a utilização
de anticorpos monoclonais, imunomoduladores e anti-inflamatórios como possíveis alternativas terapêuticas para uso em
pacientes com COVID-19, com ênfase nos mecanismos...
COVID-19/tratamiento farmacológico,
Anticuerpos Monoclonales/uso terapéutico,
Factores Inmunológicos/uso terapéutico,
Antiinflamatorios/uso terapéutico,
Ensayos Clínicos como Asunto,
Eficacia,
COVID-19/inmunología,
COVID-19/fisiopatología,
COVID-19/complicaciones,
Anticuerpos Monoclonales/farmacología,
Anticuerpos Monoclonales/inmunología,
Anticuerpos Monoclonales/efectos adversos,
Factores Inmunológicos/farmacología,
Factores Inmunológicos/inmunología,
Factores Inmunológicos/efectos adversos,
Antiinflamatorios/farmacología,
Antiinflamatorios/inmunología,
Antiinflamatorios/efectos adversos
ABSTRACT Given the global burden of tuberculosis, shortened treatment regimens with existing or repurposed drugs are needed to contribute to tuberculosis control. The long duration of treatment of drug-susceptible tuberculosis (DS-TB) is associated with nonadherence and loss to follow up, and the treatme...
Introduction: This study aimed to describe clinical trials approved by the Brazilian Health Surveillance Agency (ANVISA) and coordinated by federal university hospitals (FUHs), as well as to investigate the relationship between the number of clinical trials and the assistance provided by these FUHs. Meth...
ABSTRACT Randomized controlled trials are known to be the best tool to determine the effects of an intervention; however, most healthcare professionals are not able to adequately understand the results. In this report, concepts, applications, examples, and advantages of using visual data as a complementa...
