Argenteohyla siemersi (red-spotted Argentina frog) is a casque-headed tree frog species belonging to the Hylidae family. This species has a complex combination of anti-predator defense mechanisms that include a highly lethal skin secretion. However, biochemical composition and biological effects of this ...
Hatakeyama, Daniela Miki;
Tasima, Lídia Jorge;
Bravo-Tobar, Cesar Adolfo;
Serino-Silva, Caroline;
Tashima, Alexandre Keiji;
Rodrigues, Caroline Fabri Bittencourt;
Aguiar, Weslei da Silva;
Galizio, Nathália da Costa;
Lima, Eduardo Oliveira Venancio de;
Kavazoi, Victor Koiti;
Gutierrez-Marín, Juan David;
Farias, Iasmim Baptista de;
SantAnna, Sávio Stefanini;
Grego, Kathleen Fernandes;
Morais-Zani, Karen de;
Tanaka-Azevedo, Anita Mitico.
Variability in snake venoms is a well-studied phenomenon. However, sex-based variation of Bothrops atrox snake venom using siblings is poorly investigated. Bothrops atrox is responsible for the majority of snakebite accidents in the Brazilian Amazon region. Differences in the venom composition of Bothrop...
Antivenoms are the only validated treatment against snakebite envenoming. Numerous drawbacks pertaining to their availability, safety and efficacy are becoming increasingly evident due to low sustainability of current productions. Technological innovation of procedures generating therapeutics of higher p...
Kodama, Roberto Tadashi;
Kuniyoshi, Alexandre Kazuo;
Silva, Cristiane Castilho Fernandes da;
Cajado-Carvalho, Daniela;
Duzzi, Bruno;
Mariano, Douglas Ceolin;
Pimenta, Daniel C;
Borges, Rafael;
Silva, Wilmar Dias da;
Portaro, Fernanda Calheta Vieira.
Proteases play an important role for the proper physiological functions of the most diverse organisms. When unregulated, they are associated with several pathologies. Therefore, proteases have become potential therapeutic targets regarding the search for inhibitors. Snake venoms are complex mixtures of m...
This study was carried out in order to compare the relative bioavailability of two different formulations containing 400 mg of acetaminophen + 4 mg of phenylephrine hydrochloride + 4 mg of chlorpheniramine maleate, Test formulation (Cimegripe®) and Reference formulation (Resfenol®) in 84 healthy volunt...
Acetaminofén/análisis,
Fenilefrina/análisis,
Clorfeniramina/análisis,
Cápsulas/clasificación,
Disponibilidad Biológica,
Espectrometría de Masas/métodos,
Absorción/efectos de los fármacos,
Dosis Única,
Espectrometría de Masas en Tándem/métodos,
Estudios Cruzados,
Ayuno/efectos adversos,
34628,
Voluntarios Sanos/clasificación
It is important to study the stability of plant extracts used as active ingredients in phytotherapic medicine, as degradation of the active principles directly affects the efficacy and safety of these products. Therefore, a stability study of the hydroalcoholic extract of the species: Mikania glomerata a...
Em casos de necessidade do estabelecimento da identidade de uma pessoa, quando
não há suspeição de quem possa ser o indivíduo, e não há registros ante-mortem para
comparação, necessários para aplicação de método de identificação, pode ser
realizada a estimativa do perfil biológico (sexo, ...
Objetivo: evaluar la utilidad de la identificación directa de microorganismos en muestras de orina y hemocultivos empleando la tecnología MALDI-TOF MS, mediante el análisis de concordancia en la identificación, tiempo necesario para la obtención de un resultado y costos asociados a cada método de ...
Resumen Introducción: Pseudomonas aeruginosa es un patógeno oportunista asociado a alta morbi-mortalidad. Para cepas multi-resistentes (MDR), ceftolozano/tazobactam (CTZ) se ha autorizado por la Agencia Europea del Medicamento (EMA) para infecciones del tracto urinario complicadas, pielonefritis aguda...
Antibacterianos/farmacología,
Cefalosporinas/farmacología,
Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos,
Pseudomonas aeruginosa/efectos de los fármacos,
Tazobactam/farmacología,
Espectrometría de Masas,
Pruebas de Sensibilidad Microbiana,
Pseudomonas aeruginosa/aislamiento & purificación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Valores de Referencia,
Reproducibilidad de los Resultados
ABSTRACT The diagnosis of multiple sclerosis (MS) has changed over the last decade, but remains a composite of clinical assessment and magnetic resonance imaging to prove dissemination of lesions in time and space. The intrathecal synthesis of immunoglobulin may be a nonspecific marker and there are no p...
Biomarcadores/sangre,
Cromatografía Liquida,
Lipidómica/métodos,
Imagen por Resonancia Magnética,
Espectrometría de Masas/métodos,
Esclerosis Múltiple/sangre,
Esclerosis Múltiple/líquido cefalorraquídeo,
Esclerosis Múltiple/diagnóstico,
Valores de Referencia,
Reproducibilidad de los Resultados,
Sensibilidad y Especificidad
