Chronic hepatotoxicity is a debilitating and frequently life-threatening disease resulting in progressive liver failure. The toxic chemical, thioacetamide (TAA) is used to evaluate hepatoprotective agents, and the polyphenolic compound, resveratrol was proposed as a novel treatment for diseases with hype...
Contexto: O infliximabe é um anticorpo monoclonal quimérico que atua neutralizando a atividade biológica do fator de necrose tumoral alfa e impedindo a ligação da molécula aos receptores da célula-alvo. A melhora da psoríase ocorre logo nas primeiras semanas do seu uso, e está
indicado, especial...
Introduction: Lichen planus is one of the most common oral mucosal lesions. Transforming growth factor-β (TGF- β) has a marked effect on epithelial–mesenchymal transition and immune cells function. Vascular Endothelial Growth Factor (VEGF) is a key regulator of vasculogenesis and angiogenesis. Tumor ...
Abstract Background: Anogenital warts are the leading sexually transmitted infection in patients seeking care at specialized clinics. They may display a vast array of forms, according to the interaction of the virus with the host's immunity. Cellular immunity is the epithelium's main form of defense aga...
Enfermedades del Ano/inmunología,
Enfermedades del Ano/patología,
Condiloma Acuminado/inmunología,
Condiloma Acuminado/patología,
Estudios Transversales,
Células Dendríticas/inmunología,
Células Dendríticas/patología,
Enfermedades de los Genitales Masculinos/inmunología,
Enfermedades de los Genitales Masculinos/patología,
Inmunohistoquímica,
Células de Langerhans/inmunología,
Células de Langerhans/patología,
Estudios Prospectivos,
Valores de Referencia,
Factor de Necrosis Tumoral alfa/análisis,
Factor de Necrosis Tumoral alfa/inmunología
Abstract Introduction Obstrutive sleep apnea syndrome is characterized by repeated episodes of upper airway obstruction, associated with intermittent hypoxia and hypercapnia, and the main risk factor in childhood is adenotonsillar hypertrophy. The lymphocytes in these structures are responsible for loca...
Biomarcadores,
Proteína C-Reactiva/análisis,
Estudios Transversales,
Citocinas/inmunología,
Inflamación/inmunología,
Interleucinas/análisis,
Orosomucoide/análisis,
Tonsila Palatina/inmunología,
Tonsila Palatina/patología,
Estudios Prospectivos,
Apnea Obstructiva del Sueño/inmunología,
Tonsilectomía,
Factor de Necrosis Tumoral alfa/análisis
Abstract Objectives This study aimed to explore the effect of antidepressant treatment on the HPA axis, changes in depression score, and serum levels of TNF-α in depressed infertile women. Methods In this randomized controlled trial research, 60 infertile women who had undergone in vitro fertiliza...
Depresión/tratamiento farmacológico,
Infertilidad Femenina/psicología,
Sistema Hipotálamo-Hipofisario/efectos de los fármacos,
Factor de Necrosis Tumoral alfa/sangre,
Fertilización In Vitro,
Fluoxetina/uso terapéutico,
Resultado del Tratamiento,
Hidrocortisona/sangre,
Infertilidad Femenina/terapia,
Antidepresivos/uso terapéutico,
Factor de Necrosis Tumoral alfa/efectos de los fármacos
ABSTRACT Objective The aim of this study was to investigate polycystic ovary syndrome (PCOS) and to explore the relationship between body fat percentage and metabolic markers. Subjects and methods Sedentary women were assigned to PCOS (N = 60) and CONTROL (N = 60) groups. Each group was subdivided in...
17-alfa-Hidroxiprogesterona/sangre,
Adiponectina/sangre,
Tejido Adiposo/anatomía & histología,
Andrógenos/sangre,
Biomarcadores/sangre,
Índice de Masa Corporal,
Estudios de Casos y Controles,
Hormona Folículo Estimulante/sangre,
Glucosa/análisis,
Insulina/sangre,
Resistencia a la Insulina,
Interleucina-6/sangre,
Leptina/sangre,
Hormona Luteinizante/sangre,
Enfermedades Metabólicas/sangre,
Factor de Necrosis Tumoral alfa/sangre
A inter-relação das alterações sistêmicas com o desenvolvimento e progressão de infecções orais como a periodontite apical tem sido objeto de intensos estudos nos últimos anos. O objetivo deste trabalho foi verificar a influência da fibrose hepática (FH) na severidade da periodontite apical (P...
Citocinas,
Cirrosis Hepática,
Hígado,
Interleucina-1beta,
Interleucina-6,
Periodontitis Periapical,
Pulpa Dental,
Ratas Wistar,
Resorción Ósea,
Factor de Necrosis Tumoral alfa,
Inflamación
Purpose To investigate the effects of induction of selective liver hypothermia in a rodent model. Methods Seven male Wistar rats were subjected to 90 minutes of partial 70% liver ischemia and topic liver 26°C hypothermia (H group). Other seven male Wistar rats were subjected to 90 minutes of partial 70...
Lesión Pulmonar Aguda/patología,
Lesión Pulmonar Aguda/prevención & control,
Temperatura Corporal,
Citocinas/metabolismo,
Modelos Animales de Enfermedad,
Hipotermia Inducida/métodos,
Mediadores de Inflamación/metabolismo,
Isquemia/patología,
Hígado/irrigación sanguínea,
Hígado/patología,
Necrosis/patología,
Óxido Nítrico/metabolismo,
Óxido Nítrico Sintasa/metabolismo,
Ratas Wistar,
Daño por Reperfusión/metabolismo,
Daño por Reperfusión/patología,
Daño por Reperfusión/prevención & control,
Factor de Necrosis Tumoral alfa
Abstract Purpose To examine effects of resveratrol on renal ischemia/ reperfusion injury (I/R) in a streptozotocin (STZ)-induced diabetic rat model. Methods Twenty-four male Sprague Dawley rats were treated with STZ injection for the development of diabetes, and divided into the following groups: Sha...
