ABSTRACT BACKGROUND: The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. OBJECTIVE: To clarify the association, we conducted a meta-analysis to inve...
Pueblo Asiatico,
Estudios de Casos y Controles,
Ensayos Clínicos como Asunto,
Población Blanca,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Genotipo,
Hispánicos o Latinos,
Interleucina-10/genética,
Metaanálisis como Asunto,
Polimorfismo Genético/genética,
Regiones Promotoras Genéticas,
Literatura de Revisión como Asunto,
Factores de Riesgo,
Neoplasias Gástricas/etnología,
Neoplasias Gástricas/genética
Abstract: Background: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results. Objective: The aim here was to assess the association between GSTM1/T1 null polymorphisms and ...
ABSTRACT Objective Monocyte chemoattractant protein 1 (MCP-1) has been suggested to be involved in the pathophysiology of insulin resistance (IR); therefore, variants in the MCP-1 gene may contribute to the development of this disease. The aim of this study was to analyze the relationship of the -2518 A...
Abstract Background: Metabolic syndrome (MS) is a condition that, when associated with ischemic heart disease and cardiovascular events, can be influenced by genetic variants and determine more severe coronary atherosclerosis. Objectives: To examine the contribution of genetic polymorphisms to the exte...
This study was performed to examine whether the AF4/FMR2 family, member 1 (AFF1) rs340630 polymorphism is involved in the genetic background of rheumatoid arthritis (RA) in a Chinese population. Two different study groups of RA patients and controls (328 RA patients and 449 healthy controls in the first ...
Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with sever...
Alelos,
Lista de Verificación,
Distribución de Chi-Cuadrado,
Trastornos de la Conducta Infantil/diagnóstico,
Trastornos de la Conducta Infantil/genética,
Estudios Transversales,
Frecuencia de los Genes/genética,
Interacción Gen-Ambiente,
Genotipo,
Trastornos Mentales/diagnóstico,
Trastornos Mentales/genética,
Polimorfismo de Nucleótido Simple/genética,
Escalas de Valoración Psiquiátrica,
Receptor de Serotonina 5-HT2C/genética,
Encuestas y Cuestionarios
Physical training has been strongly recommended as a non-pharmacological treatment for coronary artery disease (CAD). Genetic polymorphisms have been studied to understand the biological variability in response to exercise among individuals. This study aimed to verify the possible influence of apolipopro...
Umbral Anaerobio/fisiología,
Apolipoproteínas B/genética,
Estudios de Casos y Controles,
Enfermedad de la Arteria Coronaria/sangre,
Enfermedad de la Arteria Coronaria/genética,
Enfermedad de la Arteria Coronaria/rehabilitación,
Frecuencia de los Genes,
Genotipo,
Frecuencia Cardíaca/fisiología,
Entrenamiento de Intervalos de Alta Intensidad/métodos,
Lípidos/sangre,
Peptidil-Dipeptidasa A/genética,
Polimorfismo Genético/genética,
Factores de Riesgo
Abstract Objective Anti-inflammatory cytokines play a crucial role in periodontitis by inhibiting synthesis of pro-inflammatory cytokines. The purpose of this study was to evaluate the effect of interleukin-10 (-597) gene polymorphism and genotype distributions on chronic periodontitis (CP) development ...
Estudios de Casos y Controles,
Periodontitis Crónica/sangre,
Periodontitis Crónica/genética,
Ensayo de Inmunoadsorción Enzimática,
Frecuencia de los Genes,
Líquido del Surco Gingival/química,
Interleucina-10/análisis,
Interleucina-6/análisis,
Interleucina-6/genética,
Persona de Mediana Edad,
Reacción en Cadena de la Polimerasa,
Polimorfismo Genético,
Valores de Referencia,
Factores de Riesgo,
Estadísticas no Paramétricas
ABSTRACT Objective: To evaluate the frequency of polymorphisms in the vascular endothelial growth factor (VEGF) gene, as well as to identify a potential risk haplotype among the polymorphic regions in this gene in patients with disc degeneration and in the Control Group. Methods: This study analyzed a ...
Alelos,
Estudios de Casos y Controles,
Frecuencia de los Genes,
Variación Genética,
Genotipo,
Haplotipos,
Degeneración del Disco Intervertebral/genética,
Imagen por Resonancia Magnética,
Persona de Mediana Edad,
Polimorfismo Genético,
Reacción en Cadena en Tiempo Real de la Polimerasa/métodos,
Medición de Riesgo,
Factores de Crecimiento Endotelial Vascular/genética,
Factores de Crecimiento Endotelial Vascular/fisiología
Matsuzaka, Camila T;
Christofolini, Denise;
Ota, Vanessa K;
Gadelha, Ary;
Berberian, Arthur A;
Noto, Cristiano;
Mazzotti, Diego R;
Spindola, Leticia M;
Moretti, Patricia N;
Smith, Marilia A C;
Melaragno, Maria I;
Belangero, Sintia I;
Bressan, Rodrigo A.
Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cog...
Estudios de Casos y Controles,
Catecol O-Metiltransferasa/genética,
Catecol O-Metiltransferasa/metabolismo,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Genotipo,
Haplotipos,
Memoria a Corto Plazo/fisiología,
Pruebas Neuropsicológicas,
Fenotipo,
Polimorfismo de Nucleótido Simple/genética,
Corteza Prefrontal/metabolismo,
Esquizofrenia/genética,
Esquizofrenia/metabolismo,
Esquizofrenia/fisiopatología
