SUMMARY: The rapid rise in obesity, particularly among children is a major public health concern that adversely affects vital organs including the liver. We sought to investigate the effect of exercise on the healing of liver cells from damage induced by high fat diet (HFD) in a rat model of hepatic stea...
RESUMO Objetivo: Descrever a doença de depósito de ésteres de colesterol (DDEC) e a importância da biópsia hepática na realização do diagnóstico. Descrição do caso: Paciente feminina, dois anos e dez meses de idade, com queixa de aumento do volume abdominal secundário à hepatomegalia há...
Abstract Purpose: To investigate thymoquinone, curcumin and a combination of these two drugs were effective or not at the growth of liver. Methods: Forty female Wistar-Albino rats distributed into five groups of eight rats each, control, thymoquinone, curcumin, and thymoquinone/curcumin groups. Pathol...
Antineoplásicos/farmacología,
Antioxidantes/farmacología,
Arginasa/sangre,
Benzoquinonas/farmacología,
Biomarcadores/sangre,
Proliferación Celular,
Ceruloplasmina/análisis,
Curcumina/farmacología,
Hepatectomía/métodos,
Antígeno Ki-67/análisis,
Hígado/patología,
Neoplasias Hepáticas/cirugía,
Regeneración Hepática/efectos de los fármacos,
Trasplante de Hígado,
Óxido Nítrico/sangre,
Ratas Wistar,
Activador de Tejido Plasminógeno/sangre
Ulomoides dermestoides is a beetle traditionally consumed to treat diabetes. In this study, we performed a composition analysis of U. dermestoides to obtain the principal fractions, which were used to assess the effect on glycemia, liver and pancreatic architecture, and PPARγ and GLUT4 expression. N...
Escarabajos/química,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/patología,
Cuerpo Adiposo/química,
Cromatografía de Gases y Espectrometría de Masas,
Regulación de la Expresión Génica,
Transportador de Glucosa de Tipo 4/efectos de los fármacos,
Transportador de Glucosa de Tipo 4/metabolismo,
Hipoglucemiantes/aislamiento & purificación,
Hipoglucemiantes/uso terapéutico,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Hígado/patología,
PPAR gamma/efectos de los fármacos,
PPAR gamma/metabolismo,
Páncreas/efectos de los fármacos,
Páncreas/metabolismo,
Páncreas/patología,
ARN Mensajero/efectos de los fármacos,
ARN Mensajero/metabolismo,
Extractos de Tejidos/aislamiento & purificación,
Extractos de Tejidos/uso terapéutico
Nacif, Lucas S;
Rocha-Santos, Vinicius;
Claro, Laura C L;
Vintimilla, Agustin;
Ferreira, Leandro A;
Arantes, Rubens M;
Pinheiro, Rafael S;
Andraus, Wellington;
Alves, Venancio A F;
D'Albuquerque, Luiz Carneiro.
OBJECTIVES: The number of pancreatic transplants has decreased in recent years. Pancreatic grafts have been underutilized compared to other solid grafts. One cause of discard is the macroscopic appearance of the pancreas, especially the presence of fatty infiltration. The current research is aimed at und...
Tejido Adiposo/patología,
Tejido Adiposo/trasplante,
Área Bajo la Curva,
Biopsia,
Índice de Masa Corporal,
Estudios Transversales,
Hígado Graso/patología,
Hígado/patología,
Hígado/ultraestructura,
Páncreas/patología,
Trasplante de Páncreas,
Tejido Parenquimatoso/patología,
Estudios Prospectivos,
Sensibilidad y Especificidad,
Donantes de Tejidos/estadística & datos numéricos
OBJECTIVE: The prognosis of patients with biliary atresia undergoing Kasai portoenterostomy is related to the timing of the diagnosis and the indication for the procedure. The purpose of the present study is to present a practical flowchart based on 257 children who underwent Kasai portoenterostomy. MET...
Factores de Edad,
Atresia Biliar/mortalidad,
Atresia Biliar/patología,
Atresia Biliar/cirugía,
Brasil/epidemiología,
Ictericia Neonatal/patología,
Ictericia Neonatal/cirugía,
Estimación de Kaplan-Meier,
Hígado/patología,
Hígado/cirugía,
Trasplante de Hígado/métodos,
Trasplante de Hígado/mortalidad,
Portoenterostomía Hepática/métodos,
Portoenterostomía Hepática/mortalidad,
Estudios Retrospectivos,
Tasa de Supervivencia,
Factores de Tiempo,
Resultado del Tratamiento
SUMMARY: Hyperglycaemia is one of the main causes for the endothelial cell (EC) damage in diabetic patients. Even though circulating endothelial progenitor cells (CEPC) could be used as a prognosis for microvascular complications, there is very little information on the islet microvasculature. We analyse...
Diabetes Mellitus Experimental/patología,
Islotes Pancreáticos/patología,
Células Progenitoras Endoteliales/patología,
Ratas Wistar,
Peso Corporal,
Glucemia,
Inmunofenotipificación,
Riñón/patología,
Hígado/patología,
Diabetes Mellitus Experimental/inmunología,
Islotes Pancreáticos/irrigación sanguínea
Abstract Objective: Several studies reported the local tissue reaction caused by mineral aggregate-based cements. However, few studies have investigated the systemic effects promoted by these cements on liver and kidney when directly applied to connective tissue. The purpose of this in vivo study was to...
Compuestos de Aluminio/farmacología,
Materiales Biocompatibles,
Compuestos de Calcio/farmacología,
Cementos Dentales/farmacología,
Combinación de Medicamentos,
Riñón/efectos de los fármacos,
Riñón/patología,
Hígado/efectos de los fármacos,
Hígado/patología,
Ensayo de Materiales,
Óxidos/farmacología,
Materiales de Obturación del Conducto Radicular/farmacología,
Silicatos/farmacología,
Factores de Tiempo
ABSTRACT Here, we evaluated whether the exposure of rats to a cafeteria diet pre- and/or post-weaning, alters histological characteristics in the White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and liver of adult male offspring. Female Wistar rats were divided into Control (CTL; fed on standard r...
Barlas, Aziz Mutlu;
Kismet, Kemal;
Erel, Serap;
Kuru, Serdar;
Cavusoglu, Turgut;
Senes, Mehmet;
Adiyaman, Zeynep;
Celepli, Pinar;
Hucumenoglu, Sema;
Pekcici, Recep.
Abstract Purpose: To investigate the potential protective effects of erdosteine against the harmful effects of ischemia-reperfusion injury on the liver in an experimental rat model. Methods: Forty rats were divided into 4 groups. In the sham group, only the hepatic pedicle was mobilized. No other mani...
