Getz, Joselito;
Goldenstein, Monica;
Bonfim, Carmem;
Funke, Vaneuza Moreira;
Colturato, Vergílio;
Hamerschlak, Nelson;
Torres, Margareth;
Sayer, David;
Boldt, Angelica;
Pasquini, Ricardo;
Pereira, Noemi Farah.
ABSTRACT Background: Immunological life-threatening complications frequently occur in post-hematopoietic stem cell transplantation (HSCT), despite matching recipient and donor (R/D) pairs for classical human leukocyte antigens (HLA). Studies have shown that R/D non-HLA disparities within the major histo...
Küchler, Erika Calvano;
Gerlach, Raquel Fernanda;
Cunha, Arthur S;
Ramazzotto, Lucas A;
Spada, Paula Porto;
Nelson-Filho, Paulo;
Ramos, Junia;
Pecharki, Giovana Daniela;
Barbosa Jr, Fernando;
Vieira, Alexandre Rezende;
Trevilatto, Paula Cristina;
Brancher, João Armando.
Abstract Homeostasis between salivary calcium and phosphorus is important for maintaining oral health. The aim of this study was to evaluate if polymorphisms in ESR1 (Estrogen Receptor Alpha), ESR2 (Estrogen Receptor Beta) and miRNA17 (microRNA17) are associated with calcium and phosphorus levels in sali...
Abstract Objective: Mannose-binding lectin, which belongs to the collectin family, is an acute-phase reactant that activates the complement system. This study aimed to investigate the effect of MBL2 gene polymorphism on short-term outcomes in preterm infants. Method: Infants of <37 gestational weeks...
Resumen: Introducción: La obesidad es una enfermedad inflamatoria donde la genética determina cierto nivel de riesgo. Aun cuando existen estudios que reportan asociación entre polimorfismos de FTO (fat-mass associated gene) y adiposidad, existe limitada evidencia en población infantil chilena. Obj...
Adiposidad/genética,
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/genética,
Predisposición Genética a la Enfermedad,
Obesidad Infantil/genética,
Polimorfismo de Nucleótido Simple,
Chile,
Estudios Transversales,
Marcadores Genéticos,
Modelos Lineales,
Obesidad Infantil/diagnóstico,
Obesidad Infantil/patología
Abstract Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different ...
Alopecia Areata/genética,
Antígeno CTLA-4/genética,
Estudios de Casos y Controles,
Frecuencia de los Genes,
Estudios de Asociación Genética,
Predisposición Genética a la Enfermedad,
Variación Genética/genética,
Técnicas de Genotipaje,
México,
Persona de Mediana Edad,
Polimorfismo de Nucleótido Simple,
Factores de Riesgo
Abstract Objective: Familial hypercholesterolemia (FH) is a monogenic disease, associated with variants in the LDLR, APOB and PCSK9 genes. The initial diagnosis is based on clinical criteria like the DLCN criteria. A score > 8 points qualifies the patient as "definite" for FH diagnosis. The detection...
ABSTRACT BACKGROUND: Intestinal cancer often occurs in type 2 diabetic patients. The concept of increasing insulin levels and insulin-like growth factor in the blood with type 2 diabetes are stimulated with the growth and depletion of cloned cell walls, and the continuation of this process leads to the...
Abstract Instruction: Noise-induced hearing loss is a leading occupational disease caused by gene-environment interaction. The Grainy Like 2, GRHL2, is a candidate gene. In this regard, many studies have evaluated the association between GRHL2 and noise-induced hearing loss, although the results are amb...
Abstract Background: Acute coronary syndrome (ACS) is a cardiovascular disease caused by obstruction of coronary arteries by atheromatous plaque. Susceptibility to this disease may be related to genetic variations, such as single nucleotide polymorphisms (SNPs). Objective: In this study, we evaluated t...
ABSTRACT Objective Type 1 diabetes mellitus (T1DM) is an autoimmune disorder caused by a complex interaction between environmental and genetic risk factors. BTB domain and CNC homolog 2 (BACH2) gene encodes a transcription factor that acts on the differentiation and formation of B and T lymphocytes. BA...
Factores de Transcripción con Cremalleras de Leucina de Carácter Básico/genética,
Brasil,
Estudios de Casos y Controles,
Diabetes Mellitus Tipo 1/genética,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Genotipo,
Persona de Mediana Edad,
Reacción en Cadena de la Polimerasa,
Polimorfismo de Nucleótido Simple/genética,
Factores de Riesgo
