Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses prostaglandins to evade innate barriers, thus enabling the parasites to survive inside immune cells. Despite the role of the enzyme Phospholipase A2 (PLA2) in prostaglandins ...
The Malaria Frontier Hypothesis (MFH) is the current model for predicting malaria emergence in the Brazilian Amazon. It has two important dimensions, 'settlement time' and 'malaria incidence', and its prediction are: malaria incidence peaks five years after the initiation of human settlement and declines...
BACKGROUND Visceral leishmaniasis is a major public health challenge in South America, and dogs are its main urban reservoir. OBJECTIVE Validation of the canine Dual-path Platform immunoassay for canine visceral leishmaniasis (DPP® CVL) for a sample set composed of 1446 dogs from different Brazilian end...
Torrellas, Annhymariet;
Ferrer, Elizabeth;
Cruz, Israel;
Lima, Héctor de;
Delgado, Olinda;
Rangel, José Carrero;
Bravo, José Arturo;
Chicharro, Carmen;
Llanes-Acevedo, Ivonne Pamela;
Miles, Michael A;
Feliciangeli, María Dora.
BACKGROUND The transmission routes for American cutaneous leishmaniasis (ACL) are in flux, so studies examining its transmission in humans, mammalian hosts, and sand fly vectors are urgently needed. OBJECTIVES The aim of this work was understand the epidemiological cycles of Leishmania spp., which causes...
Several studies have described the use of non-invasive collection methods, mostly based on the detection of parasite DNA, for diagnosis. However, no Leishmania specimens have been isolated from saliva. Here, we report the first isolation of Leishmania braziliensis from the saliva of humans with cutaneous...
Toxoplasma gondii uses epigenetic mechanisms to regulate both endogenous and host cell gene expression. To identify genes with putative epigenetic functions, we developed an in silico pipeline to interrogate the T. gondii proteome of 8313 proteins. Step 1 employs PredictNLS and NucPred to identify genes ...
Amebiasis is the infection by Entamoeba histolytica, a protozoan capable of invading the colonic mucosa
causing a diarrheic syndrome, although most of the time is mild, it can lead to a fulminating colitis. Sometimes it can spread to other organs; among extra-intestinal manifestations of this parasite, t...
Lazcano-Pérez, Fernando;
Zavala-Moreno, Ariana;
Rufino-González, Yadira;
Ponce-Macotela, Martha;
García-Arredondo, Alejandro;
Cuevas-Cruz, Miguel;
Gómez-Manzo, Saúl;
Marcial-Quino, Jaime;
Arreguín-Lozano, Barbarín;
Arreguín-Espinosa, Roberto.
Cnidarian venoms and extracts have shown a broad variety of biological activities including cytotoxic, antibacterial and antitumoral effects. Most of these studied extracts were obtained from sea anemones or jellyfish. The present study aimed to determine the toxic activity and assess the antitumor and a...
BACKGROUND Trypanosoma cruzi is a protozoan parasite and an etiological agent of Chagas disease. There is a wide variability in the clinical outcome of its infection, ranging from asymptomatic individuals to those with chronic fatal mega syndromes. Both parasite and host factors, as well as their interpl...
Resumen Introducción El diagnóstico de toxoplasmosis congénita (TC) en el recién nacido es muy importante porque debe recibir tratamiento siempre, sintomático o no, para evitar o aminorar las secuelas de la enfermedad. Objetivo Evaluación comparativa de los métodos disponibles en la institución...
Reacción en Cadena de la Polimerasa/métodos,
Pruebas Serológicas/métodos,
Toxoplasma/aislamiento & purificación,
Toxoplasmosis Congénita/diagnóstico,
Anticuerpos Antiprotozoarios/sangre,
Ensayo de Inmunoadsorción Enzimática/métodos,
Técnicas de Genotipaje,
Isotipos de Inmunoglobulinas/sangre,
Complicaciones Parasitarias del Embarazo/diagnóstico,
Complicaciones Parasitarias del Embarazo/parasitología,
Reproducibilidad de los Resultados,
Sensibilidad y Especificidad,
Toxoplasma/genética,
Toxoplasma/patogenicidad,
Toxoplasmosis Congénita/inmunología,
Toxoplasmosis Congénita/parasitología
