SUMMARY: Retinoic acid, an active metabolite of vitamin A, plays essential signaling roles in mammalian embryogenesis. Prenatal rat fetuse exposure to retinoid induces some malformations in various organs, the most active and teratogenic metablolite is all-transretinoic acid (atRA). The teratogenic effec...
SUMMARY: An alternative superovulator to replace clomiphene citrate is needed as clomiphene citrate is associated with low pregnancy rates. Anastrozole is an effective superovulator, but it has not been well researched. In order to determine the effectiveness of anastrozole as a superovulator and to comp...
Nitrilos/farmacología,
Triazoles/farmacología,
Vinculina/efectos de los fármacos,
Integrinas/efectos de los fármacos,
Adhesiones Focales/efectos de los fármacos,
Microscopía Confocal,
Microscopía Fluorescente,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Útero/efectos de los fármacos,
Células Epiteliales/efectos de los fármacos,
Vinculina/fisiología,
Vinculina/genética,
Integrinas/fisiología,
Integrinas/genética,
Ratas Wistar
Abstract The aim of this study was to evaluate the influence of the prophylactic and therapeutic supplementation with omega 3 polyunsaturated fatty acids (w-3 PUFAs) on the lipid profile and periapical bone resorption in rats with apical periodontitis. Forty male rats were divided into groups: control ra...
Abstract Introduction To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications. Objective In thi...
Oxigenoterapia Hiperbárica,
Inflamación/sangre,
Inflamación/patología,
Inflamación/prevención & control,
Interleucina-10/sangre,
Interleucina-1beta/sangre,
Cuello,
Estrés Oxidativo,
Traumatismos Experimentales por Radiación/sangre,
Traumatismos Experimentales por Radiación/patología,
Traumatismos Experimentales por Radiación/prevención & control,
Ratas Wistar,
Factor de Necrosis Tumoral alfa/sangre
Abstract Introduction The literature has reported the association between lead and auditory effects, based on clinical and experimental studies. However, there is no consensus regarding the effects of lead in the auditory system, or its correlation with the concentration of the metal in the blood. Obje...
ABSTRACT Considering that thiol-containing enzymes like kinases are critical for several metabolic pathways and energy homeostasis, we investigated the effects of cystine dimethyl ester and/or cysteamine administration on kinases crucial for energy metabolism in the kidney of Wistar rats. Animals were in...
Adenilato Quinasa/análisis,
Adenilato Quinasa/efectos de los fármacos,
Creatina Quinasa/análisis,
Creatina Quinasa/efectos de los fármacos,
Cisteamina/farmacología,
Cistina/análogos & derivados,
Cistina/farmacología,
Depletores de Cistina/farmacología,
Disulfuros,
Homeostasis/efectos de los fármacos,
Riñón/efectos de los fármacos,
Compuestos de Sulfhidrilo,
Ratas Wistar,
Reproducibilidad de los Resultados
ABSTRACT Dyslipidemias are associated with the incidence of cardiovascular diseases, obesity, diabetes, hypertension and hepatic steatosis, being the cause of morbidity and mortality. This study investigated the effects of lychee peel flour (PF) on serum levels of total cholesterol (TC), low-density lipo...
Alanina Transaminasa/sangre,
Aspartato Aminotransferasas/sangre,
Colesterol/sangre,
Dieta Alta en Grasa,
Hígado Graso/sangre,
Hígado Graso/dietoterapia,
Hígado Graso/prevención & control,
Hipercolesterolemia/sangre,
Hipercolesterolemia/dietoterapia,
Hipercolesterolemia/prevención & control,
Peroxidación de Lípido,
Lipoproteínas LDL/sangre,
Litchi/química,
Hígado/efectos de los fármacos,
Sustancias Protectoras/farmacología,
Ratas Wistar
ABSTRACT The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. ...
Antiinflamatorios/farmacología,
Antiinflamatorios/toxicidad,
Carragenina,
Modelos Animales de Enfermedad,
Edema/inducido químicamente,
Edema/tratamiento farmacológico,
Miembro Posterior,
Mediadores de Inflamación,
Péptidos/efectos de los fármacos,
Ratas Wistar,
Salicilatos/farmacología,
Salicilatos/toxicidad,
Factores de Tiempo,
Triptaminas/farmacología,
Triptaminas/toxicidad
SUMMARY: Supplementation is a strategy to potentiate physical training through hypertrophy of skeletal muscles, but other tissues such as the prostate may also be affected. Changes in prostate size and function are associated with the behavior of individuals, but evidence for an association with suppleme...
Anselmo, Natassia Alberici;
Paskakulis, Leticia Colombo;
Garcias, Renata Correia;
Botelho, Fernanda Fortuci Resende;
Toledo, Giovana Queda;
Cury, Maria Fernanda Ribeiro;
Carvalho, Natiele Zanardo;
Mendes, Glória Elisa Florido;
Iembo, Tatiane;
Bizotto, Thaís Santana Gastardelo;
Cury, Patricia Maluf;
Chies, Agnaldo Bruno;
Carlos, Carla Patrícia.
ABSTRACT Introduction: Ischemia-reperfusion (IR) injury results from inflammation and oxidative stress, among other factors. Because of its anti-inflammatory and antioxidant properties, the Brazil nut (BN) might attenuate IR renal injury. Objective: The aim of the present study was to investigate wheth...
