This study was aimed to search the effect of wheatgrass on the Total Antioxidan (TAS)-Oxidan Status (TOS) and DNA damage in rat with diabetes. The rats used in the study were randomly divided into 4 groups that each of has 10 rats: Control group; 1 ml single dose phosphate-citrate buffer injected i.p (pH...
Triticum/química,
Extractos Vegetales/administración & dosificación,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Antioxidantes/análisis,
Estrés Oxidativo/efectos de los fármacos,
Páncreas/efectos de los fármacos,
Ratas Wistar,
Daño del ADN/efectos de los fármacos,
Oxidantes/sangre,
Células Secretoras de Insulina/efectos de los fármacos,
Extractos Vegetales/farmacología,
Glucemia/efectos de los fármacos
In vertebrates, the inflammatory reaction is responsible for modulating the initial nonspecific defense until specific immunity is acquired. In this context, numerous studies in mammals have demonstrated the participation of insulin in the inflammatory response, favoring cell proliferation and the migrat...
Kidney injury secondary to diabetes is the most common cause of kidney failure. We sought to determine whether pretreatment with the insulin-sensitizing drug metformin prior to the induction of diabetes can protect the kidney against the development of diabetic nephropathy (DN) induced by a combination o...
Abstract Purpose: To evaluate if Moringa oleifera leaf aqueous extract (ME) influences the healing of skin wounds of diabetic rats. Methods: Wistar rats were used (6 rats/group). Group 1 received normal saline (NS) v.o. Group 2 received moringa extract (100mg/kg v.o) for 3 weeks. Groups 3 and 4: Stre...
Abstract Purpose: To investigate the specific molecular mechanisms and effects of curcumin derivative J147 on diabetic peripheral neuropathy (DPN). Methods: We constructed streptozotocin (STZ)-induced DPN rat models to detected mechanical withdrawal threshold (MWT) in vivo using Von Frey filaments. I...
Proteínas Quinasas Activadas por AMP/análisis,
Proteínas Quinasas Activadas por AMP/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Western Blotting,
Calcio/análisis,
Supervivencia Celular/efectos de los fármacos,
Células Cultivadas,
Curcumina/análogos & derivados,
Curcumina/farmacología,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/metabolismo,
Neuropatías Diabéticas/tratamiento farmacológico,
Neuropatías Diabéticas/metabolismo,
Microscopía Fluorescente,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reproducibilidad de los Resultados,
Estreptozocina,
Canal Catiónico TRPA1/análisis,
Canal Catiónico TRPA1/efectos de los fármacos,
Factores de Tiempo
Abstract Purpose: To investigate the effects of melatonin on antioxidant capacity, inflammation and apoptotic cell death (through expression of cleaved-caspase 3) in lung tissue samples of diabetic rats. Methods: Thirty male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control...
Antioxidantes/farmacología,
Caspasa 3/análisis,
Caspasa 3/efectos de los fármacos,
Catalasa/análisis,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/patología,
Glutatión/análisis,
Inmunohistoquímica,
Peroxidación de Lípido,
Pulmón/efectos de los fármacos,
Pulmón/metabolismo,
Pulmón/patología,
Malondialdehído/análisis,
Melatonina/farmacología,
Peroxidasa/análisis,
Piroptosis/efectos de los fármacos,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Reproducibilidad de los Resultados,
Estreptozocina,
Superóxido Dismutasa/análisis,
Factores de Tiempo
Abstract Purpose: To investigate the cause of congenital anomalies resulted from gestational diabetes on fetal cardiac tissue in experimental animal study model. Methods: Totally 12 female Wistar albino rats were divided into two groups, each consisting of 6 rats. Streptozotocin (60 mg/kg) was administ...
Antioxidantes/análisis,
Glucemia/análisis,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Gestacional,
Corazón/embriología,
Cardiopatías Congénitas/embriología,
Cardiopatías Congénitas/etiología,
Cardiopatías Congénitas/patología,
Hiperglucemia/complicaciones,
Microscopía,
Miocardio/patología,
Miocitos Cardíacos/patología,
Estrés Oxidativo,
Ratas Wistar,
Valores de Referencia,
Estreptozocina
Yilmaz, Nezih;
Uysal, Ibrahim;
Eratilla, Veysel;
Sevgi, Irtegün;
Günes Uysal, Rojdan Ferman;
Eratilla, Elif;
Hüseyin, Elbey;
Ersin, Uysal;
Deveci, Busra;
Deveci, Engin.
SUMMARY: The purpose of this study was to investigate effects of diabetes mellitus (DM) on the alveolar bone with histopathological and immunohistochemical methods. Wistar rats were divided into two groups, control and diabetes group. Control group was fed standard rat chow and drinking water for 8 weeks...
Abstract Purpose: To analyzed the healing effect of the powdered shell of the Megalobulimus lopesi snail on wounds of diabetic rats, since in non-diabetic rats the powdered shell presented healing potential. Methods: Seventy-two Wistar rats (Rattus norvegicus albinus) were divided into three groups: C...
Administración Tópica,
Exoesqueleto/química,
Antiinflamatorios/administración & dosificación,
Antiinflamatorios/farmacología,
Diabetes Mellitus Experimental/fisiopatología,
Modelos Animales de Enfermedad,
Polvos,
Ratas Wistar,
Repitelización,
Caracoles,
Extractos de Tejidos/administración & dosificación,
Extractos de Tejidos/farmacología,
Cicatrización de Heridas/efectos de los fármacos
Abstract To evaluate the impact of the GaAlAs diode laser with energy densities of 160 J/cm2, 320 J/cm2, and 640 J/cm2 on the periodontal tissues under continuous orthodontic force application and on the rate of orthodontic tooth movement in rats with type-2 diabetes mellitus. The intensity of primary al...
Pérdida de Hueso Alveolar/patología,
Diabetes Mellitus Experimental,
Diabetes Mellitus Tipo 2/fisiopatología,
Inmunohistoquímica,
Láseres de Semiconductores/uso terapéutico,
Terapia por Luz de Baja Intensidad/métodos,
Aparatos Ortodóncicos,
Osteoclastos/efectos de la radiación,
Osteocitos/efectos de la radiación,
Osteogénesis/efectos de la radiación,
Osteopontina/análisis,
Periodoncio/diagnóstico por imagen,
Periodoncio/patología,
Periodoncio/efectos de la radiación,
Dosis de Radiación,
Radiografía,
Distribución Aleatoria,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Técnicas de Movimiento Dental/métodos
