Dias, Vinicius Luderer;
Braga, Karina Andrighetti de Oliveira;
Nepomuceno, Natalia Aparecida;
Ruiz, Liliane Moreira;
Perez, Juan David Ruiz;
Correia, Aristides Tadeu;
Caires Junior, Luiz Carlos de;
Goulart, Ernesto;
Zatz, Mayana;
Pêgo-Fernandes, Paulo Manuel.
RESUMO Objetivo A escassez de pulmões viáveis ainda é um grande obstáculo para o transplante. As vítimas de trauma, que constituem potenciais doadores de pulmão, comumente apresentam choque hipovolêmico que acarreta inflamação e deterioração pulmonar e rejeição após o transplante. Buscando...
Abstract Fish consumption plays an important role in human diet. Hoplias malabaricus, commonly known as traíra, is a freshwater fish widely appreciated in several Brazilian states and frequently infected by Eustrongylides sp. fourth-instar larvae (L4). The aim of the present study was to evaluate allerg...
OBJECTIVES: In addition to the classic motor symptoms of Parkinson's disease (PD), patients also present with non-motor symptoms, such as autonomic dysfunction, which is present in almost 90% of patients with PD, affecting the quality of life and mortality. Regarding sex differences in prevalence and pre...
Viana, G S B;
Vale, E M do;
Araujo, A R A de;
Coelho, N C;
Andrade, S M;
Costa, R O da;
Aquino, P E A de;
Sousa, C N S de;
Medeiros, I S de;
Vasconcelos, S M M de;
Neves, K R T.
Ketamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid (30 min) and long-lasting (15 and 30 days after) anti...
Research on the prevention of post-traumatic epilepsy (PTE) has seen remarkable advances regarding its physiopathology in recent years. From the search for biomarkers that might be used to indicate individual susceptibility to the development of new animal models and the investigation of new drugs, a gre...
ABSTRACT Purpose: To assess the biochemical, histological, histomorphometric and molecular effects of biliary duct ligation (BDL) induced liver cirrhosis in the heart and kidneys. Methods: Thirty-two weaning rats (21 days old, 50-70 g) underwent BDL and were divided in four groups (euthanasia after two...
Abstract Trichinellosis is a zoonosis results from eating raw or semi-cooked meat of infected animals. Medicinal plants have been used lately as alternatives and/or combined therapies to resolve some drawbacks of the current regimens. This work analyzed the effect of albendazole monotherapy on Trichinell...
Albendazol,
Amigdalina,
Modelos Animales de Enfermedad,
Larva,
Miositis/veterinaria,
Extractos Vegetales,
Granada (Fruta),
Trichinella spiralis,
Triquinelosis/tratamiento farmacológico,
Triquinelosis/veterinaria,
Vitamina B 12
Sun, Bo;
Li, Fangda;
Lai, Song;
Zhang, Xu;
Wang, Hongxia;
Li, Yuan;
Wang, Wei;
Chen, Yuexin;
Liu, Bao;
Zheng, Yuehong.
ABSTRACT Purpose To investigate the relationship between atherosclerotic abdominal aortic aneurysm (AAA) and CXC chemokine receptor type 2 (CXCR2). Methods Mouse AAA model was established by embedding angiotensin-II pump (1000 ng/kg/min) in ApoE-/- mice. Mice were received SB225002, a selective CXCR2 a...
BACKGROUND: Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα in DR. METHODS: Human retinal capillary pericytes (HRCPs) were treated with high g...
ADN (Citosina-5-)-Metiltransferasa 1/metabolismo,
Retinopatía Diabética,
PPAR alfa/genética,
Retina/patología,
Apoptosis,
Células Cultivadas,
Metilación de ADN,
Diabetes Mellitus,
Modelos Animales de Enfermedad,
Metilación,
Regiones Promotoras Genéticas,
Retina/citología
BACKGROUND: Heart failure (HF) is the leading cause of death in western countries. Cardiac dysfunction is accompanied by skeletal alterations resulting in muscle weakness and fatigue. Exercise is an accepted interventional approach correcting cardiac and skeletal dysfunction, thereby improving mortality,...
