ABSTRACT Objective The objective of this study was to evaluate the role of oxidative stress in an experimental model of streptozotocin-induced diabetic nephropathy in rats. Materials and methods Wistar, adult, male rats were used in the study. Animals were divided in the following groups: Citrate (co...
ABSTRACT Objective Endothelial dysfunction (ED) plays an important role in the pathogenesis of diabetic nephropathy. The purpose of the study was to determine flow mediated endothelial dependent vasodilatation (FMD) measurements and serum soluble (s) endothelin-1 (ET-1), intercellular adhesion molecule...
Background: Patients with lupus nephritis could progress to endstage renal disease (10-22%); hence, kidney transplants should be considered as the treatment of choice for these patients. Objective: To evaluate the clinical outcomes after kidney transplants in patients with chronic kidney diseases seconda...
ABSTRACT PURPOSE : To investigate in the kidney the pathologic changes and expression of GRP78 and CHOP in the Kunming (KM) mice with combination of high-fat diet and streptozotocin-induced diabetes. METHODS : Sixty two male KM mice were randomly divided into a normal control (NC) group (n=20) and a hi...
La nefropatía diabética es una complicación grave en la diabetes mellitus. Sus principales cambios morfológicos típicos se deben al aumento de la cantidad de proteínas de la matriz extracelular. Los productos finales de glicación avanzada, resultado de la hiperglucemia, estimulan la producción de...
Introdução: O fator de crescimento transformante beta-1 (TGFβ1) é uma citocina multifuncional que regula a proliferação, a diferenciação
e a formação da matriz extracelular de vários tipos de células. Existem evidências de que os polimorfismos -509C>T e
869T>C no gene do TGFβ1 alteram a sua...
La disfunción ventricular izquierda es una complicación frecuente en las personas con diabetes mellitus 1. Es objetivo del trabajo determinar si la excreción urinaria de albúmina se asocia a la presencia de disfunción ventricular izquierda en personas normotensas con diabetes mellitus 1 de largo tie...