In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The der...
In this study, a dichloromethane fraction dry extract from the underground parts of Jatropha isabellei (DFJi) was used to prepare lipid nanocarriers (LNCJi) aimed at providing the oral delivery of terpenic compounds in the treatment of arthritis. The lipid nanocarriers were prepared by the spontaneous em...
Abstract In an attempt to increase molecular stability and provide controlled release, vascular endothelial growth factor (VEGF) was encapsulated into polycaprolactone (PCL) nanoparticles. Both VEGF-free and VEGF-loaded PCL nanoparticles were formulated by w/o/w double emulsion of the dichloromethane-wat...
Abstract Posaconazole exerts an extended spectrum of antifungal activity against various strains of clinically relevant moulds and yeasts. In recent years, antifungal triazole posaconazole has become increasingly important for the prophylaxis and treatment of systemic mycoses. After oral administration o...
Disolución,
Administración Oral,
Cristalización/instrumentación,
Disponibilidad Biológica,
Eficiencia,
Espectroscopía Infrarroja por Transformada de Fourier,
Esguinces y Distensiones/diagnóstico,
Levaduras/clasificación,
Micosis/patología,
Preparaciones Farmacéuticas,
Técnicas In Vitro/métodos,
Ácido Clorhídrico
Abstract The aim of the current study was to assess the physicochemical characteristics and wound healing activity of chitosan-polyvinyl alcohol (PVA) crosslinked hydrogel containing recombinant human epidermal growth factor (rh-EGF) or recombinant mouse epidermal growth factor (rm-EGF). The hydrogels we...
Abstract Objective: To compare the high-cycle fatigue behavior of four commercially available NiTi orthodontic wires. Material and Methods: Twelve NiTi orthodontic wires, round, 0.016-in, three per brand, were selected and divided into four groups: G1 - Heat-activated NiTi, G2 - Superelastic NiTi, G3 -...
Rodrigues, Gabriella Fernandes;
Monteiro, Amanda Souza Nunes;
Vollú, Ana Lúcia;
Pires, Paula Maciel;
Silva, Aline Saddock de Sá;
Lopes, Ricardo Tadeu;
Oliveira, Branca Heloisa;
Neves, Aline de Almeida;
Barja-Fidalgo, Fernanda;
Fonseca-Gonçalves, Andréa.
Abstract Objective: To evaluate the efficacy of silver diamine fluoride (SDF) in arresting dentin caries lesions when applied under different concentrations and times. Material and Methods: Forty-two bovine blocks were selected and fixed in 24-well plates. Each well received a mixed bacterial inoculum ...
Estadísticas no Paramétricas,
Técnicas In Vitro/métodos,
Caries Dental/epidemiología,
Cariostáticos/uso terapéutico,
Dentina,
Estudios Longitudinales,
Remineralización Dental,
Diaminas/química,
Fluoruros/química,
Microtomografía por Rayos X/instrumentación,
Plata/uso terapéutico,
Biopelículas
Abstract In the hospital environment, postoperative pain is a common occurrence that impairs patient recovery and rehabilitation and lengthens hospitalization time. Racemic bupivacaine hydrochloride (CBV) and Novabupi® (NBV) (S (-) 75% R (+) 25% bupivacaine hydrochloride) are two examples of local anest...
Abstract Despite decades of research, wound healing remains a significant public health problem. This study aimed to develop and evaluate a topical sodium alginate gel containing vancomycin (Van) loaded MMT NPs for wound healing applications. Van was loaded in MMT at different conditions (pHs of 6, 7 and...
Técnicas In Vitro/métodos,
Vancomicina/agonistas,
Infección de Heridas/patología,
Alginatos/análisis,
Bentonita/antagonistas & inhibidores,
Cicatrización de Heridas/efectos de los fármacos,
Antibacterianos/clasificación,
ddcs0285700,
Espectroscopía Infrarroja por Transformada de Fourier/métodos,
Heridas y Lesiones/tratamiento farmacológico,
d0121060,
Preparaciones Farmacéuticas/administración & dosificación
Abstract Serrapeptase, a proteolytic enzyme, has been used for the adjuvant treatment of many diseases. However, its fibrinolytic activity is still uncertain. Herein, the fibrinolytic activity of serrapeptase and its in vitro thrombolytic effects were investigated. The results showed that the fibrinolyti...
