Results: 1019

Displacers improve the selectivity of phosphopeptide enrichment by metal oxide affinity chromatography

Abstract: Background: A key process in cell regulation is protein phosphorylation, which is catalyzed by protein kinases and phosphatases. However, phosphoproteomics studies are difficult because of the complexity of protein phosphorylation and the number of phosphorylation sites. Methods: We describ...

Proteomics: a tool to develop novel diagnostic methods and unravel molecular mechanisms of pediatric diseases

Abstract: Proteomics is the study of the expression of changes and post-translational modifications (PTM) of proteins along a metabolic condition either normal or pathological. In the field of health, proteomics allows obtaining valuable data for treatment, diagnosis or pathophysiological mechanisms of d...

Omics-based biomarkers: current status and potential use in the clinic

Abstract: In recent years, the use of high-throughput omics technologies has led to the rapid discovery of many candidate biomarkers. However, few of them have made the transition to the clinic. In this review, the promise of omics technologies to contribute to the process of biomarker development is des...

Omics techniques and biobanks to find new biomarkers for the early detection of acute lymphoblastic leukemia in middle-income countries: a perspective from Mexico

Abstract: Acute lymphoblastic leukemia (ALL) affects the quality of life of many children in the world and particularly in Mexico, where a high incidence has been reported. With a proper financial investment and with well-organized institutions caring for those patients, together with solid platforms to ...

Identifying sleep apnoea and hypopnoea episodes from respiratory polygraphy signals

Rev. colomb. psiquiatr; 46 (2), 2017
Abstract Objective: To design a diagnostic support system for sleep apnoea and hypopnoea syndrome (SAHS) using moving average based on knowledge, able to identify SAHS episodes from a respiratory polygraphy (RP) database. Methods: An analysis was made of data obtained from a public database, that inc...

Preferencias y satisfacción hacia un programa de tamizaje con pruebas autoadministradas de detección del virus de papiloma humano

Estudio transversal que describe preferencias y satisfacción hacia un programa de tamizaje de cáncer cervical con pruebas rápidas autoadministradas, para la detección del virus de papiloma humano (VPH). De las 2090 usuarias captadas por el programa en Ventanilla Callao-Perú, se seleccionó aleatoria...

Real-time PCR assay for the diagnosis of pleural tuberculosis

Colomb. med; 48 (2), 2017
Abstract Introduction: The diagnosis of pleural tuberculosis requires an invasive and time-consuming reference method. Polymerase chain reaction (PCR) is rapid, but validation in pleural tuberculosis is still weak. Objective: To establish the operating characteristics of real-time polymerase chain re...

Mutational spectrum in breast cancer associated BRCA1 and BRCA2 genes in Colombia

Colomb. med; 48 (2), 2017
Abstract Introduction: The risk of developing breast and ovarian cancer is higher in families that carry mutations in BRCA1 or BRCA2 genes, and timely mutation detection is critical. Objective: To identify the presence of mutations in the Colombian population and evaluate two testing strategies. Met...

Estudio de propiedades moleculares de cuatro flavonoides de Baccharis boliviensis

Con-ciencia (La Paz); 5 (1), 2017
En este trabajo de investigación se realizó un estudio de relación estructura y actividad antioxidante empleando métodos computacionales basándose en propiedades estructurales y electrónicas, para lograr este objetivo se utilizó el programa computacional Hyperchem versión 8.0.1 empleando métodos...

A produção científica na perspectiva da complexidade da angústia de labirinto à fundação da liberdade

Con-ciencia (La Paz); 5 (1), 2017
Desde el punto de vista de la teoría de la complejidad de Morin, este trabajo se concentra en el proceso de investigación científica e de adquisición de conocimiento. La pesquisa está basada en algunos trabajos importantes de Morin (2000, 2003, 2010, 2015), Torre (2005), Moraes (2002, 2015), Bueno (...