Vesentini, G;
Marini, G;
Piculo, F;
Damasceno, DC;
Matheus, SMM;
Felisbino, SL;
Calderon, IMP;
Hijaz, A;
Barbosa, AMP;
Rudge, MVC.
The urethral muscle of diabetic pregnant rats is affected by long-term mild diabetes and short-term severe diabetes, which plays a crucial role in the pathogenesis of pelvic floor disorders. We hypothesized that muscles outside the pelvis are subject to similar changes. The current study aimed at analyzi...
Ulomoides dermestoides is a beetle traditionally consumed to treat diabetes. In this study, we performed a composition analysis of U. dermestoides to obtain the principal fractions, which were used to assess the effect on glycemia, liver and pancreatic architecture, and PPARγ and GLUT4 expression. N...
Escarabajos/química,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/patología,
Cuerpo Adiposo/química,
Cromatografía de Gases y Espectrometría de Masas,
Regulación de la Expresión Génica,
Transportador de Glucosa de Tipo 4/efectos de los fármacos,
Transportador de Glucosa de Tipo 4/metabolismo,
Hipoglucemiantes/aislamiento & purificación,
Hipoglucemiantes/uso terapéutico,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Hígado/patología,
PPAR gamma/efectos de los fármacos,
PPAR gamma/metabolismo,
Páncreas/efectos de los fármacos,
Páncreas/metabolismo,
Páncreas/patología,
ARN Mensajero/efectos de los fármacos,
ARN Mensajero/metabolismo,
Extractos de Tejidos/aislamiento & purificación,
Extractos de Tejidos/uso terapéutico
Farnesoid X receptor (FXR) and related pathways are involved in the therapeutic effect of sleeve gastrectomy for overweight or obese patients with diabetes mellitus. This study aimed to investigate the mechanism of FXR expression regulation during the surgical treatment of obese diabetes mellitus by slee...
Western Blotting,
Diabetes Mellitus Experimental/metabolismo,
Gastrectomía/métodos,
Regulación de la Expresión Génica,
Metabolismo de los Lípidos,
Hígado/metabolismo,
Factor de Transcripción MafB/genética,
Factor de Transcripción MafB/metabolismo,
Obesidad/metabolismo,
Obesidad/cirugía,
Proteínas Oncogénicas/genética,
Proteínas Oncogénicas/metabolismo,
Ratas Sprague-Dawley,
Receptores Citoplasmáticos y Nucleares/genética,
Receptores Citoplasmáticos y Nucleares/metabolismo,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
ABSTRACT The present study investigates the effect of cinnamon (Cinnamomum zeylanicumon) powder supplementation on glucose levels, lipid profiles, and oxidative stress parameters in alloxan-induced diabetic rats. Diabetes was induced in adult male Wistar rats via a single subcutaneous alloxan injection (...
Kuga, Gabriel Keine;
Gaspar, Rafael Calais;
Muñoz, Vitor Rosetto;
Nakandakari, Susana Castelo Branco Ramos;
Breda, Leonardo;
Sandoval, Bruna Marina;
Caetano, Flávio Henrique;
Leme, José Alexandre Curiacos de Almeida;
Pauli, José Rodrigo;
Gomes, Ricardo José.
ABSTRACT Objective To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. Methods Wistar rats were randomized into four groups: sedentary control, trained control, sedentary diabetic and trained diabetic. Diabetes mellitus was induced by Alloxan (3...
Glucemia/metabolismo,
Peso Corporal,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/metabolismo,
Prueba de Esfuerzo,
Insulina,
Factor I del Crecimiento Similar a la Insulina/metabolismo,
Hígado/anatomía & histología,
Hígado/metabolismo,
Hígado/ultraestructura,
Glucógeno Hepático/metabolismo,
Mitocondrias Hepáticas/ultraestructura,
Condicionamiento Físico Animal/fisiología,
Distribución Aleatoria,
Ratas Wistar,
Natación/fisiología
Moraes, Oscar Albuquerque de;
Flues, Karin;
Scapini, Kátia Bilhar;
Mostarda, Cristiano;
Evangelista, Fabiana de Sant'Anna;
Rodrigues, Bruno;
Dartora, Daniela Ravizzoni;
Fiorino, Patricia;
Angelis, Kátia De;
Irigoyen, Maria Cláudia.
OBJECTIVES: The present study aimed to investigate cardiovascular autonomic modulation and angiotensin II (Ang II) activity in diabetic mice that were genetically engineered to harbor two or three copies of the angiotensin-converting enzyme gene. METHODS: Diabetic and non-diabetic mice harboring 2 or 3 ...
Angiotensina II/análisis,
Angiotensina II/metabolismo,
Sistema Nervioso Autónomo/fisiopatología,
Glucemia/análisis,
Sistema Cardiovascular/fisiopatología,
Diabetes Mellitus Experimental/fisiopatología,
Dosificación de Gen/fisiología,
Frecuencia Cardíaca/fisiología,
Inmunohistoquímica,
Riñón/enzimología,
Peptidil-Dipeptidasa A/genética,
Reacción en Cadena de la Polimerasa,
Distribución Aleatoria,
Nervio Vago/fisiopatología
BACKGROUND: Diabetic nephropathy (DN) is the leading cause of end-stage renal failure, contributing to severe morbidity and mortality in diabetic patients. Berberine (BBR) has been well characterized to exert renoprotective effects in DN progression. However, the action mechanism of BBR in DN remains to ...
Abstract Activity of hepatic metabolic enzymes of glucuronidation and sulfation of 4-nitrophenol (PNP) and biliary excretion of its glucuronide (PNP-G) and sulfate (PNP-S) conjugates have been investigated in control and streptozotocin (STZ)-induced diabetic rats. 500 μM PNP solution was luminally perf...
ABSTRACT Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin...
Abstract Objective To evaluate whether hyperbaric oxygen (HBO) treatment has a favorable effect on implant osseointegration in diabetic rabbits. Material and Methods An experimental diabetes model was induced in 32 New Zealand rabbits through IV injection of alloxan. After the state of diabetes had b...
Aloxano,
Regeneración Ósea/fisiología,
Interfase Hueso-Implante/fisiología,
Implantación Dental Endoósea/métodos,
Diabetes Mellitus Experimental/fisiopatología,
Oxigenoterapia Hiperbárica/métodos,
Oseointegración/fisiología,
Conejos,
Reproducibilidad de los Resultados,
Tibia/cirugía,
Factores de Tiempo,
Resultado del Tratamiento,
Cicatrización de Heridas
