Results: 120

Overexpression of UHRF1 gene correlates with the major clinicopathological parameters in urinary bladder cancer

Int. braz. j. urol; 43 (2), 2017
ABSTRACT Introduction Recently, expression of the UHRF1 gene was found to be up-regulated in numerous neoplasms, including the urinary bladder transitional cell carcinoma (TCC). Objective The aim of our study was to determine if the expression levels of UHRF1 gene correlates with the major pathologic...

Endoscopic prediction of tumor invasion depth in early gastric neoplasia: a prospective study in Peru

Introduction: Endoscopic resection is the first option treatment of early gastric cancer with invasion to mucosa or superficial submucosa, because the risk of nodal metastasis is negligible. Then the prediction of tumor invasion is cardinal. Objectives: Determine the accuracy of endoscopic prediction for...

Angiolymphatic invasion as a prognostic fator in resected N0 pancreatic adenocarcinoma

ABCD (São Paulo, Impr.); 30 (1), 2017
ABSTRACT Background: Pancreatic adenocarcinoma remains one of the worst digestive cancers. Surgical resection is the main target when treating a patient with curative intent. Aim: To assess angiolymphatic invasion as a prognostic factor in resected pN0 pancreatic cancer. Methods: Thirty-eight patients...

Which features of advanced head and neck basal cell carcinoma are associated with perineural invasion?

Abstract Introduction Perineural invasion is a unique route for tumor dissemination. In basal cell carcinomas, the incidence is low, but increases in advanced cases. Its importance is recognized but not fully understood. Objective To compare head and neck basal cell carcinomas with and without perineur...

A novel model to estimate lymph node metastasis in endometrial cancer patients

Clinics; 72 (1), 2017
OBJECTIVES: To evaluate the postoperative pathological characteristics of hysterectomy specimens, preoperative cancer antigen (CA)-125 levels and imaging modalities in patients with endometrial cancer and to build a risk matrix model to identify and recruit patients for retroperitoneal lymphadenectomy. ...

Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer?

Braz. j. med. biol. res; 50 (7), 2017
Breast cancer is the most common cancer among women and its metastatic potential is responsible for numerous deaths. Thus, the need to find new targets for improving treatment, and even finding the cure, becomes increasingly greater. Ion channels are known to participate in several physiological function...

BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma

Biol. Res; 50 (), 2017
BACKGROUND: Bromodomain-containing protein 4 (BRD4) inhibition is a new therapeutic strategy for many malignancies. In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migration and invasion of salivary adenoid cystic carcinoma (SACC). METHODS: The human norma...

Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma

Biol. Res; 50 (), 2017
BACKGROUND: Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC. RESULTS: We have found th...

Laparoscopic Radical Cystectomy in the Elderly - Results of a Single Center LRC only Series

Int. braz. j. urol; 42 (6), 2016
ABSTRACT Objective: To compare outcome of laparoscopic radical cystectomy (LRC) with ileal conduit in 22 elderly ( (≥75 years) versus 51 younger (<75 years) patients. patients. Materials and Methods: Analysis of prospectively gathered data of a single institution LRC only series was performed. Select...

Hoarseness: an unusual presentation of primary thyroid lymphoma with laryngeal infiltration