According to the information provided by the World Health Organization (WHO), overweight and obesity are the fifth leading causes of death in the world. Due to the alarming increase of this disorder in recent years, studies have been carried out to evidence harmful effects on human or animal tissues. Our...
Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disorder with progressive clinical signs until death, around the second decade of life. Mdx is the most used animal model to pre-clinical studies of DMD. Parameters of exercise on this muscular disease are still unknown. This research aimed to ...
Abstract Background: The cardiac hypertrophy (CH) model for mice has been widely used, thereby providing an effective research foundation for CH exploration. Objective: To research the effects of CH modeling under abdominal aortic constriction (AAC) using different needles and weights in mice. Methods...
Aorta Abdominal,
Peso Corporal,
Cardiomegalia/etiología,
Cardiomegalia/patología,
Constricción,
Modelos Animales de Enfermedad,
Ecocardiografía,
Ligadura/instrumentación,
Ratones Endogámicos C57BL,
Agujas/normas,
Distribución Aleatoria,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factores de Tiempo
Abstract Purpose: To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Methods: The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate the possible role of IL-4 signaling pathwa...
Antiinflamatorios/farmacología,
Antineoplásicos Fitogénicos/efectos adversos,
Western Blotting,
Citocinas/análisis,
Citocinas/efectos de los fármacos,
Modelos Animales de Enfermedad,
Regulación hacia Abajo/efectos de los fármacos,
Hiperalgesia/inducido químicamente,
Hiperalgesia/tratamiento farmacológico,
Interleucina-4/farmacología,
Ratones Endogámicos C57BL,
Ratones Noqueados,
Fármacos Neuroprotectores,
Enfermedades del Sistema Nervioso Periférico/inducido químicamente,
Enfermedades del Sistema Nervioso Periférico/metabolismo,
Enfermedades del Sistema Nervioso Periférico/prevención & control,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reproducibilidad de los Resultados,
Factor de Transcripción STAT6/análisis,
Factor de Transcripción STAT6/efectos de los fármacos,
Factores de Tiempo,
Resultado del Tratamiento,
Vincristina/efectos adversos
ABSTRACT Neurocysticercosis (NCC) is one of the parasitic infections that most affects the central nervous system. The knowledge regarding its immunopathogenesis and pathophysiology needs broadening. Taenia crassiceps cysticerci are used as the NCC experimental model. The aim of this work was to describe...
Modelos Animales de Enfermedad,
Ensayo de Inmunoadsorción Enzimática,
Interferón gamma/sangre,
Interferón gamma/inmunología,
Interleucina-10/sangre,
Interleucina-10/inmunología,
Interleucina-4/sangre,
Interleucina-4/inmunología,
Ratones Endogámicos C57BL,
Neurocisticercosis/inmunología,
Neurocisticercosis/patología,
Taenia/inmunología,
Células Th2/inmunología
OBJECTIVES: Several compounds characterized by an olefin linkage conjugated to a carbonyl group have anti-inflammatory properties. The diuretic ethacrynic acid (EA) is a compound of this type. Herein, we tested the hypothesis that ethacrynic acid can modulate the development of ileus after bowel manipula...
Modelos Animales de Enfermedad,
Ácido Etacrínico/farmacología,
Tránsito Gastrointestinal/efectos de los fármacos,
Ileus/patología,
Ileus/cirugía,
Mediadores de Inflamación/antagonistas & inhibidores,
Interleucina-6/antagonistas & inhibidores,
Intestino Delgado/efectos de los fármacos,
Intestino Delgado/patología,
Ratones Endogámicos C57BL,
Óxido Nítrico Sintasa de Tipo II/antagonistas & inhibidores,
Complicaciones Posoperatorias,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
OBJECTIVES: Dietary omega-3 fatty acids have been efficacious in decreasing serum cholesterol levels and reducing the risk of cardiovascular disease. However, the metabolic and molecular changes induced by the omega-3 fatty acid α-linolenic acid (ALA), which is found in linseed oil, are not fully un...
Dieta Alta en Grasa,
Suplementos Dietéticos,
Estrés del Retículo Endoplásmico/efectos de los fármacos,
Ácidos Grasos Omega-3/administración & dosificación,
Ácidos Grasos Omega-3/farmacología,
Hígado Graso/prevención & control,
Prueba de Tolerancia a la Glucosa,
Inflamación/prevención & control,
Resistencia a la Insulina,
Ratones Endogámicos C57BL,
Ácido alfa-Linolénico/administración & dosificación,
Ácido alfa-Linolénico/farmacología
The imbalance between bone formation and osteolysis plays a key role in the pathogenesis of aseptic loosening. Strontium ranelate (SR) can promote bone formation and inhibit osteolysis. The aim of this study was to explore the role and mechanism of SR in aseptic loosening induced by wear particles. Twent...
The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most frequently studied in the central nervous system and has been linked to neuropathic pain. In this study, a post-translational mechanism of microRNA (miR)-186 via regulating the expression of NLRP3 in the complete Freu...
Western Blotting,
Modelos Animales de Enfermedad,
Ensayo de Inmunoadsorción Enzimática,
Adyuvante de Freund,
Estudios de Asociación Genética,
Inflamasomas/análisis,
Inflamasomas/fisiología,
Interleucina-18/análisis,
Interleucina-18/metabolismo,
Interleucina-1beta/análisis,
Interleucina-1beta/metabolismo,
Luciferasas,
Ratones Endogámicos C57BL,
MicroARNs/farmacología,
Análisis por Micromatrices,
Proteína con Dominio Pirina 3 de la Familia NLR/análisis,
Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo,
Distribución Aleatoria,
Valores de Referencia,
Factores de Tiempo,
Neuralgia del Trigémino/tratamiento farmacológico
BACKGROUND: Chemokine (C-C motif) receptor 6 (CCR6) is present in sperm and plays a significant role in sperm motility and chemotaxis acting in the reproductive tracts. However, the expression and functional significance of CCR6 in testis are still poorly understood, especially in the process of spermato...
Quimiocina CCL20/metabolismo,
Quimiotaxis/fisiología,
Receptores CCR6/metabolismo,
Espermatogénesis/fisiología,
Criptorquidismo/metabolismo,
Motilidad Espermática/fisiología,
Testículo/fisiología,
Western Blotting,
Técnica del Anticuerpo Fluorescente,
Inmunohistoquímica,
Ratones Endogámicos C57BL,
Células de Sertoli
