ABSTRACT Background: The prevalence of keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) (HTLV-1/KCS) has been estimated at around 37%, but its clinical manifestations are poorly described. Purpose: To determine the prevalence and associated factors of HTL...
Distribución por Edad,
Factores de Edad,
Brasil/epidemiología,
Estudios Transversales,
ADN Viral,
Ensayo de Inmunoadsorción Enzimática,
Virus Linfotrópico T Tipo 1 Humano/patogenicidad,
Queratoconjuntivitis Seca/epidemiología,
Queratoconjuntivitis Seca/patología,
Queratoconjuntivitis Seca/virología,
Distribución de Poisson,
Prevalencia,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores Sexuales,
Factores Socioeconómicos,
Carga Viral
SUMMARY OBJECTIVE: This study aims to evaluate the sleep of subjects with polycystic ovary syndrome (PCOS), with and without hyperandrogenism, in comparison with a healthy control group and examine the effects of hyperandrogenism and obesity on sleep parameters. METHODS: A total of 44 volunteers were r...
Wu, Xue-Liang;
Wang, Yuan-Yuan;
Wang, Li-Kun;
Xue, Jun;
Yang, Dong-Dong;
Qu, Ming;
Wang, Chen-Yu;
Guo, Fei;
Yang, Rui-Min;
Liu, Bo.
SUMMARY BACKGROUND: This study aims to investigate the expression of Id-1 in human colorectal adenocarcinoma tissues and explore its correlation with the clinical pathological parameters of colorectal cancer. METHODS: The Id-1 mRNA and protein expression levels of 50 specimens of normal colorectal tiss...
SUMMARY OBJECTIVE: Our study aimed to investigate the diagnostic value of lncRNA H19 for coronary artery disease (CAD) and to explore its possible mechanisms. Methods: A total of 30 CAD patients and 30 healthy individuals, as well as patients with different cardiovascular diseases, were included in thi...
Biomarcadores/sangre,
Estudios de Casos y Controles,
Enfermedad de la Arteria Coronaria/sangre,
Enfermedad de la Arteria Coronaria/diagnóstico,
Ensayo de Inmunoadsorción Enzimática,
Persona de Mediana Edad,
ARN Largo no Codificante/sangre,
Curva ROC,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factor de Crecimiento Transformador beta1/sangre,
Regulación hacia Arriba
ABSTRACT Objective: To evaluate the influence of sub-minimum inhibitory concentrations (MICs) of ciprofloxacin (CIP) on biofilm formation and virulence factors of Escherichia coli clinical isolates. Methods: Sub-MICs of CIP were determined using growth curve experiments. The biofilm-forming capacity of...
Antibacterianos/farmacología,
Biopelículas/efectos de los fármacos,
Ciprofloxacina/farmacología,
Escherichia coli/efectos de los fármacos,
Escherichia coli/genética,
Expresión Génica/efectos de los fármacos,
Violeta de Genciana,
Pruebas de Sensibilidad Microbiana,
Microscopía Electrónica de Rastreo,
Valores de Referencia,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores de Tiempo,
Factores de Virulencia
Abstract INTRODUCTION: Insect cell cultures play an essential role in understanding arboviral replication. However, the replicative efficiency of some of these viruses such as dengue (DENV), yellow fever (YFV), and chikungunya (CHIKV) in a new cellular substrate (Lulo) and in the other two recognized ce...
Exosomes, a kind of extracellular vesicle, are promising therapeutic agents for spinal cord injury (SCI). This article aimed to investigate effects of exosomes secreted from miRNA-29b-modified bone marrow mesenchymal stem cells (BMSCs) on SCI. Exosomes were extracted from BMSCs transfected with miRNA-29b...
Baicalein (BAI) is an acknowledged flavonoids compound, which is regarded as a useful therapeutic pharmaceutical for numerous cancers. However, its involvement in melanoma is largely unknown. This study aimed to examine the anti-melanoma function of BAI and unraveled the regulatory mechanism involved. A3...
Western Blotting,
Línea Celular Tumoral,
Movimiento Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Regulación hacia Abajo/efectos de los fármacos,
Flavanonas/farmacología,
Regulación Neoplásica de la Expresión Génica/efectos de los fármacos,
Melanoma/patología,
Invasividad Neoplásica,
ARN Largo no Codificante/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. In this study, we observed that malignant melanoma tissue showed NOP14 ...
Apoptosis,
Western Blotting,
Línea Celular Tumoral,
Movimiento Celular,
Proliferación Celular,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Metástasis Linfática,
Melanoma/metabolismo,
Melanoma/secundario,
Proteínas Nucleares/genética,
Proteínas Nucleares/metabolismo,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Neoplasias Cutáneas/metabolismo,
Neoplasias Cutáneas/patología,
Vía de Señalización Wnt/genética,
beta Catenina/genética,
beta Catenina/metabolismo
SUMMARY: In spite of being one of the most powerful anti-cancer drug, the nephrotoxicity of Vincristine (VCR) is not well established in either animals or humans. Hence, this study evaluates the nephrotoxic effect of VCR in rats after sub-chronic long-term administration. Rats were divided into 2 groups ...
Vincristina/toxicidad,
Enfermedades Renales/inducido químicamente,
Estrés Oxidativo/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Riñón/efectos de los fármacos,
MAP Quinasa Quinasa 1,
Proteína Quinasa 3 Activada por Mitógenos,
Sistema de Señalización de MAP Quinasas,
Ratas Wistar,
Creatinina/sangre,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Western Blotting,
Riñón/patología,
Tasa de Supervivencia,
ARN Mensajero,
Urea/sangre,
Necrosis
