Diabetes mellitus is a frequent and serious metabolic illness all over the world and plants have been a desirable source of medicine recently. Diabetes has unpleasant effect on male reproductive system and it may lead to male infertility. It causes erectile dysfunction and reduces ejaculate volume by aff...
Santos-Júnior, Luciano;
Oliveira, Tassia Virgínia de Carvalho;
Cândido, Janaína Farias;
Santana, Danielle Souza de;
Pereira Filho, Rose Nely;
Pereyra, Beatriz Benny Sungaila;
Gomes, Margarete Zanardo;
Lima, Sônia Oliveira;
Albuquerque-Júnior, Ricardo Luiz Cavalcanti de;
Cândido, Edna Aragão Farias.
Abstract Purpose: To investigate the cellular response to injury, analyzing histopathologic changes associated with increased cellularity, degeneration and disorganization of collagen fibers. Methods: Thirty wistar rats were divided in two groups after partial Achilles tenotomy: the right hind paw were...
Abstract Purpose: To investigate the effects of dexmedetomidine (DEX) on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury (I/R). Methods: Thirty-six, male, Wistar rats were randomly divided into three groups: the sham operation group (group C), the i...
Aminoácidos/efectos de los fármacos,
Aminoácidos/metabolismo,
Isquemia Encefálica/tratamiento farmacológico,
Isquemia Encefálica/metabolismo,
Corteza Cerebral/química,
Corteza Cerebral/ultraestructura,
Dexmedetomidina/farmacología,
Glutamina/metabolismo,
Fármacos Neuroprotectores/farmacología,
Ratas Wistar,
Daño por Reperfusión/metabolismo,
Ácido gamma-Aminobutírico/efectos de los fármacos,
Ácido gamma-Aminobutírico/metabolismo
Abstract Purpose: To investigate the hepatoprotective and antioxidant effeicacies of Silybum marianum's (silymarin, S) on University of Wisconsin (UW) and histidinetryptophan-ketoglutarate (HTK) preservation solutions. Methods: Thirty two Wistar albino adult male rats were used. Group 1: UW group, Grou...
Adenosina,
Alopurinol,
Antioxidantes/uso terapéutico,
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Glucosa,
Glutatión,
Inmunohistoquímica,
Insulina,
Manitol,
Soluciones Preservantes de Órganos,
Cloruro de Potasio,
Procaína,
Sustancias Protectoras/uso terapéutico,
Rafinosa,
Ratas Wistar,
Silimarina/uso terapéutico
ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group (n= ...
Anomalías Inducidas por Medicamentos,
Ascomicetos/química,
Benzofuranos/química,
Benzofuranos/toxicidad,
Peso Fetal/efectos de los fármacos,
Feto/efectos de los fármacos,
Hepatocitos/efectos de los fármacos,
Ácido Láctico/química,
Ácido Láctico/toxicidad,
Líquenes/química,
Hígado/efectos de los fármacos,
Hígado/patología,
Exposición Materna,
Ácido Poliglicólico/química,
Ácido Poliglicólico/toxicidad,
Copolímero de Ácido Poliláctico-Ácido Poliglicólico,
Distribución Aleatoria,
Ratas Wistar,
Valores de Referencia
BISPO, VANDERSON S;
DANTAS, LUCAS S;
CHAVES FILHO, ADRIANO B;
PINTO, ISABELLA F D;
SILVA, RAILMARA P DA;
OTSUKA, FELIPE A M;
SANTOS, RODRIGO B;
SANTOS, ALINE C;
TRINDADE, DANIELLE J;
MATOS, HUMBERTO R.
ABSTRACT Hepatic disorders such as steatosis and alcoholic steatohepatitis are common diseases that affect thousands of people around the globe. This study aims to identify the main phenol compounds using a new HPLC-ESI+-MS/MS method, to evaluate some oxidative stress parameters and the hepatoprotective ...
Antioxidantes/farmacología,
Ácido Ascórbico/farmacología,
Ácidos Cafeicos/farmacología,
Colesterol/sangre,
Cocos/química,
Daño del ADN/efectos de los fármacos,
Etanol/farmacología,
Peroxidación de Lípido,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar,
Reproducibilidad de los Resultados,
Espectrometría de Masas en Tándem,
Sustancias Reactivas al Ácido Tiobarbitúrico,
Factores de Tiempo,
Triglicéridos/sangre,
Agua/farmacología
ABSTRACT Objective: To evaluate the effects of exposure to emissions from sugar cane burning on inflammatory mechanisms in tissues of the trachea and lung parenchyma in Wistar rats after different periods of exposure. Methods: This was an experimental open randomized study. The animals were divided int...
Contaminantes Atmosféricos/toxicidad,
Colágeno/análisis,
Incineración,
Exposición por Inhalación/efectos adversos,
Pulmón/efectos de los fármacos,
Pulmón/patología,
Modelos Animales,
Distribución Aleatoria,
Ratas Wistar,
Factores de Riesgo,
Saccharum,
Humo/efectos adversos,
Factores de Tiempo,
Tráquea/efectos de los fármacos,
Tráquea/patología
O Câncer de cólon é um dos tipos mais comuns de câncer no mundo e a segunda principal causa de morte relacionada a esta doença em países desenvolvidos. Até 75% dos casos estão associados com a alimentação, indicando que uma pessoa pode reduzir o seu risco simplesmente através de modificação ...
Flaxseed is considered a functional food with several health benefits. However, because of its high phytoestrogen content, flaxseed influences hormone metabolism and affects the gonadal biomorphology. In this study, computerized histomorphometry was used to evaluate seminiferous and epididymal tubules, c...
ABSTRACT BACKGROUND Severe Acute Liver Failure (ALF) is a life-threatening clinical syndrome characterized by hepatocyte necrosis, loss of hepatic architecture, and impairment of liver functions. One of the main causes of ALF is hepatotoxicity from chemical agents, which damage hepatocytes and result in...
Alanina Transaminasa/sangre,
Fosfatasa Alcalina/sangre,
Antioxidantes/uso terapéutico,
Aspartato Aminotransferasas/sangre,
Modelos Animales de Enfermedad,
Fallo Hepático Agudo/enzimología,
Fallo Hepático Agudo/patología,
Fallo Hepático Agudo/prevención & control,
Ratas Wistar,
Especies de Nitrógeno Reactivo/metabolismo,
Especies Reactivas de Oxígeno/metabolismo,
Índice de Severidad de la Enfermedad,
Vitamina E/uso terapéutico
