Results: 1740

Applicability of a novel mathematical model for the prediction of adult height and age at menarche in girls with idiopathic central precocious puberty

Clinics; 73 (), 2018
OBJECTIVES: Unfavorable predicted adult height and psychosocial inadequacy represent parameters used to guide therapeutic intervention in girls with central precocious puberty. Gonadotropin-releasing hormone analog is the first-line treatment. The aim of this study was to compare two methods used to pred...

Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer

Clinics; 73 (), 2018
OBJECTIVE: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of ...

Intraoperative imprint cytology versus histological diagnosis for the detection of sentinel lymph nodes in breast cancer treated with neoadjuvant chemotherapy

Clinics; 73 (), 2018
OBJECTIVES: To compare imprint cytology and paraffin section histology for sentinel lymph node detection in women with breast cancer treated with neoadjuvant chemotherapy. METHOD: A cross-sectional study and report of the sentinel lymph node statuses of 64 patients with breast cancer who underwent intra...

Clinical application of atlantoaxial pedicle screw placement assisted by a modified 3D-printed navigation template

Clinics; 73 (), 2018
OBJECTIVES: To investigate the primary clinical value of atlantoaxial pedicle screw placement assisted by a modified 3D-printed navigation template. METHODS: We retrospectively analyzed the cases of 17 patients treated from June 2015 to September 2016 with atlantoaxial pedicle screw placement assisted b...

Limiares de audibilidade de altas frequências em indivíduos adultos normo-ouvintes

CoDAS; 30 (4), 2018
RESUMO Objetivo Avaliar os limiares auditivos nas altas frequências, buscando comparar as respostas entre as orelhas, verificar a correlação do nível de audibilidade com o aumento da idade e analisar as respostas por frequência para adultos normo-ouvintes. Método Este estudo foi prospectivo, qu...

Validity and test-retest reliability of the Brazilian version of the Return-to-work self-efficacy questionnaire

ABSTRACT OBJECTIVE To investigate the validity and test-retest reliability of the Brazilian version of the Dutch questionnaire "Verwachtingen over werken". METHODS We analyzed data from a longitudinal study conducted in the city of São Paulo, Brazil, from 2014 to 2016. Participants were 411 workers ...

Granulocyte colony-stimulating factor combined with Methylprednisolone improves functional outcomes in rats with experimental acute spinal cord injury

Clinics; 73 (), 2018
OBJECTIVES: To evaluate the effects of combined treatment with granulocyte colony-stimulating factor (G-CSF) and methylprednisolone in rats subjected to experimental spinal cord injury. METHODS: Forty Wistar rats received a moderate spinal cord injury and were divided into four groups: control (no treat...

Aplicação de uma prova brasileira de vocabulário expressivo em crianças falantes do Português Europeu

CoDAS; 30 (2), 2018
RESUMO Objetivo investigar o desempenho de crianças falantes do Português Europeu em prova brasileira de vocabulário expressivo, buscando apontar se existem diferenças entre as faixas etárias e o gênero, além de verificar sua aplicabilidade nesta população. Método a amostra foi constituída...

Interleukin-12 as a biomarker of the beneficial effects of food restriction in mice receiving high fat diet or high carbohydrate diet

Braz. j. med. biol. res; 51 (12), 2018
The impact of food restriction (FR) during 56 days on serum levels of cytokines in mice fed a high-fat diet (HFD) or high-carbohydrate diet (HCD) were evaluated. The amount of food was reduced 50% for HFD-FR and HCD-FR groups compared to mice receiving free access to HFD (HFD group) or HCD (HCD group). W...

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate

Mem. Inst. Oswaldo Cruz; 113 (10), 2018
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GG...