This is the fourteenth edition of this database of evidence on potential therapeutic options for COVID-19, in which 68 therapeutic options are examined. This information will help investigators, policy makers, and prescribers navigate the flood of relevant data to ensure that management of COVID-19, at b...
Breder, J S C;
Pires, A L R;
Azevedo, F F;
Apolinário, P P;
Cantaruti, T;
Jiwani, S I;
Moraes, Â M;
Consonni, S R;
Araújo, E P;
Adams, G G;
Saad, M J A;
Lima, M H M.
The use of specially designed wound dressings could be an important alternative to facilitate the healing process of wounds in the hyperglycemic state. Biocompatible dressings combining chitosan and alginate can speed up wound healing by modulating the inflammatory phase, stimulating fibroblast prolifera...
Alginatos/administración & dosificación,
Vendajes,
Materiales Biocompatibles/administración & dosificación,
Biomarcadores/sangre,
Proliferación Celular/efectos de los fármacos,
Quitosano/administración & dosificación,
Colágeno/efectos de los fármacos,
Diabetes Mellitus Experimental/fisiopatología,
Inflamación/prevención & control,
Ratones Endogámicos C57BL,
Factores de Tiempo,
Cicatrización de Heridas/efectos de los fármacos
Total Panax notoginseng saponin (TPNS) is the main bioactivity compound derived from the roots and rhizomes of Panax notoginseng (Burk.) F.H. Chen. The aim of this study was to investigate the effectiveness of TPNS in treating vascular neointimal hyperplasia in rats and its mechanisms. Male Sprague-Dawle...
Traumatismos de las Arterias Carótidas/etiología,
Traumatismos de las Arterias Carótidas/prevención & control,
Hiperplasia,
Inmunohistoquímica,
Neointima/patología,
Panax notoginseng/efectos de los fármacos,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Saponinas/farmacología,
Transducción de Señal,
Regulación hacia Arriba,
Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo
Eosinophils are abundant in the reproductive tract, contributing to the remodeling and successful implantation of the embryo. However, the mechanisms by which eosinophils migrate into the uterus and their relationship to edema are still not entirely clear, since there are a variety of chemotactic factors...
Data about the feasibility and safety of thoracoscopic surgery under non-intubated anesthesia and regional block are limited. In this prospective study, 57 consecutive patients scheduled for thoracoscopic surgery were enrolled. Patients were sedated with dexmedetomidine and anesthetized with propofol and...
Anestesia General/métodos,
Presión Sanguínea/efectos de los fármacos,
Presión Sanguínea/fisiología,
Dexmedetomidina/administración & dosificación,
Estudios de Factibilidad,
Frecuencia Cardíaca/efectos de los fármacos,
Frecuencia Cardíaca/fisiología,
Máscaras Laríngeas,
Bloqueo Nervioso/métodos,
Propofol/administración & dosificación,
Estudios Prospectivos,
Remifentanilo/administración & dosificación,
Toracoscopía/métodos
Wunderlich, A L M;
Azevedo, S C S F;
Yamada, L A;
Bataglini, C;
Previate, C;
Campanholi, K S S;
Pereira, P C S;
Caetano, W;
Kaplum, V;
Nakamura, C V;
Nakanishi, A B S;
Comar, J F;
Pedrosa, M M D;
Godoi, V A F.
Photodynamic therapy (PDT) promotes cell death, and it has been successfully employed as a treatment resource for neuropathic complications of diabetes mellitus (T1DM) and hepatocellular carcinoma. The liver is the major organ involved in the regulation of energy homeostasis, and in pathological conditio...
Clorofila/administración & dosificación,
Clorofila/análogos & derivados,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/patología,
Quimioterapia Combinada,
Metabolismo Energético/efectos de los fármacos,
Glucólisis/efectos de los fármacos,
Glucólisis/fisiología,
Hígado/patología,
Hígado/fisiopatología,
Estrés Oxidativo/efectos de los fármacos,
Estrés Oxidativo/fisiología,
Fotoquimioterapia,
Fármacos Fotosensibilizantes/administración & dosificación,
Ratas Wistar
This study aimed to investigate the therapeutic effect of fasudil on treating experimental autoimmune neuritis (EAN). Twenty-four EAN mice were randomly assigned to fasudil treatment (Fasudil group) or saline treatment (EAN model group) for 28 days. Clinical symptom score was evaluated every other day; i...
Interferón gamma/sangre,
Interleucinas/sangre,
Ratones Endogámicos C57BL,
Neuritis Autoinmune Experimental/sangre,
Neuritis Autoinmune Experimental/tratamiento farmacológico,
ARN Mitocondrial,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Nervio Ciático/efectos de los fármacos,
Nervio Ciático/metabolismo,
Linfocitos T Colaboradores-Inductores/efectos de los fármacos,
Factores de Tiempo
Alegre, Patricia;
Mathias, Livia;
Lourenço, Maria Angelica;
Santos, Priscila Portugal dos;
Gonçalves, Andrea;
Fernandes, Ana Angélica;
Gaiolla, Paula Schmidt Azevedo;
Minicucci, Marcos Ferreira;
Zornoff, Leonardo;
Paiva, Sergio Alberto Rupp;
Polegato, Bertha Furlan.
Abstract Background: Euterpe oleracea Mart. (açaí) is a fruit with high antioxidant capacity and could be an adjuvant strategy to attenuate ischemia-reperfusion injury. Objective: To evaluate the influence of açaí in global ischemia-reperfusion model in rats. Methods: Wistar rats were assigned to ...
Abstract Objective: The phytohormone abscisic acid (ABA) as a signaling molecule exists in various types of organisms from early multicellular to animal cells and tissues. It has been demonstrated that ABA has an antinociceptive effect in rodents. The present study was designed to assess the possible r...
Ácido Abscísico/farmacología,
Analgésicos/farmacología,
Western Blotting,
Proteínas Quinasas Dependientes de AMP Cíclico/análisis,
Proteínas Quinasas Dependientes de AMP Cíclico/efectos de los fármacos,
Quinasas MAP Reguladas por Señal Extracelular/análisis,
Quinasas MAP Reguladas por Señal Extracelular/efectos de los fármacos,
Péptidos y Proteínas de Señalización Intracelular/farmacología,
Reguladores del Crecimiento de las Plantas/farmacología,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Médula Espinal/efectos de los fármacos,
Médula Espinal/metabolismo,
Factores de Tiempo
Resumo A reversão da escavação é uma entidade rara que se refere à redução da escavação do disco óptico em resposta à diminuição sustentada dos níveis de pressão intra-ocular (PIO), em cerca de 25% da PIO basal. A ocorrência deste fenômeno apenas com o tratamento clínico é pouco relata...
Agudeza Visual,
Presión Intraocular/efectos de los fármacos,
Glaucoma/diagnóstico,
Glaucoma/tratamiento farmacológico,
Glaucoma/fisiopatología,
Prostaglandinas Sintéticas/uso terapéutico,
Disco Óptico/patología,
Soluciones Oftálmicas/uso terapéutico,
Fondo de Ojo,
Oftalmoscopía,
Tonometría Ocular,
Gonioscopía,
Tomografía de Coherencia Óptica,
Timolol/uso terapéutico
