Results: 5034

Possible mechanisms involved in the effect of the subchronic administration of rosuvastatin on endothelial function in rats with metabolic syndrome

Braz. j. med. biol. res; 53 (2), 2020
Metabolic syndrome is a multifaceted condition associated with a greater risk of various disorders (e.g., diabetes and heart disease). In a rat model of metabolic syndrome, an acute in vitro application of rosuvastatin causes relaxation of aortic rings. Since the outcome of a subchronic rosuvastatin trea...

Efeito da educação musical na promoção do desempenho escolar em crianças

CoDAS; 32 (1), 2020
RESUMO Objetivo Este estudo investigou o efeito da educação musical no repertório de habilidades escolares em crianças expostas e não expostas à educação musical. Método Foram avaliadas 80 crianças, entre oito a doze anos, ambos os sexos, divididos em dois grupos: 40 alunos com educação mus...

Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways

Braz. j. med. biol. res; 53 (2), 2020
Aliskiren (ALS) is well known for its antihypertensive properties. However, the potential underlying the molecular mechanism and the anti-hypertrophic effect of ALS have not yet been fully elucidated. The aim of the present study was to investigate the role of ALS in mammalian target of rapamycin (mTOR) ...

Inhibition of miR-383 suppresses oxidative stress and improves endothelial function by increasing sirtuin 1

Braz. j. med. biol. res; 53 (2), 2020
Previous research has shown that suppression of miR-383 can prevent inflammation of the endothelium, as well as postpone the development of atherosclerosis. However, the role of miR-383 in endothelial cell apoptosis in diabetes remains unclear. The aim of this study was to investigate the function of miR...

Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes

Abstract The aim of this study was to assess the influence of cyclosporine administration on the repair of critical-sized calvaria defects (CSDs) in rat calvaria filled with diverse biomaterials. Sixty animals were divided into two groups: the control (CTR) group (saline solution) and the cyclosporine (C...

Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice

Abstract Lipoproteins are important bacterial immunostimulating molecules capable of inducing receptor activator of nuclear factor-κB (RANKL) and osteoclast formation in vitro and in vivo . Although these molecules are present in periodontopathogenic bacteria, their role in periodontitis is not know...

Adhesive resistance of a copaiba oil-based dentin biomodifier

Abstract This study analyzed the effect of prior application of copaiba oil (CO) emulsions as a dentin cleaning substance on microleakage and microtensile adhesive strength. Twenty-five premolars and sixty-four molars were used for microleakage and microtensile assays. For the microleakage assays, specim...

O uso de pino de fibra em dentes tratados endodonticamente

Este estudo envolve um estudo in sílico, um ensaio clínico randomizado e duas revisões sistemáticas com o objetivo de compreender a influência dos pinos de fibra (PF) na resistência à fratura de dentes tratados endodonticamente e restaurados e também, avaliar o efeito de tratamentos químicos den...

Extratos glicólicos de Pfaffia paniculata K E Juglans regia L: avaliação do potencial antimicrobiano, anti-inflamatório, citotóxico e genotóxico

A resistência antimicrobiana atingiu proporções alarmantes em todo o mundo, sendo que na Europa mortes causadas por micro-organismos multirresistentes superam os índices de mortalidade da AIDS, tuberculose e a gripe. Assim a fitoterapia desponta no combate a esta problemática, com as diversas ativid...

Antibiofilm efficacy of tea tree oil and of its main component terpinen-4-ol against Candida albicans

Abstract Candida infection is an important cause of morbidity and mortality in immunocompromised patients. The increase in its incidence has been associated with resistance to antimicrobial therapy and biofilm formation. The aim of this study was to evaluate the efficacy of tea tree oil (TTO) and its mai...