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Phytochemical profile, in vitro activities, and toxicity of optimized Eugenia uniflora extracts

Almeida, Lucas F. de; dos Santos, Ewelyn C. F; Machado, Janaina C. B; de Oliveira, Alisson M; Napoleão, Thiago H; Ferreira, Magda R. A; Soares, Luis A. L.
Bol. latinoam. Caribe plantas med. aromát; 22 (1), 2023
In this study, we investigated the influence of mixture design on the chemical profile of Eugenia unifloraleaves, evaluating the antioxidant and antimicrobial activities, the toxic and hemolytic potential, with the focus on the improvement of the polyphenol’s extraction for in...
Eugenia/química, Extractos Vegetales/química, Hemolíticos, Fitoquímicos, Antiinfecciosos/química, Antiinfecciosos/toxicidad, Antioxidantes, Taninos/análisis, Flavonoides/análisis, Cromatografía Líquida de Alta Presión, Espectrofotometría/métodos, Análisis de Varianza, Bacterias/efectos de los fármacos, Hongos/efectos de los fármacos, Pruebas de Sensibilidad Microbiana, Extractos Vegetales/farmacología, Antiinfecciosos/farmacología
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Scarless two-stage delayed coloanal anastomosis: a technique description

Bendib, Hani; Oukrine, Hind; Djelali, Nabil; Lahrech, Said; Elbahi, Ameur; Chekman, Chemseddine; Azzouz, Abdelghani; Anou, Abdelkrim; Djennaoui, Azeddine.
J. coloproctol. (Rio J., Impr.); 43 (1), 2023
Introduction: In current clinical practice, immediate coloanal anastomosis (ICA) remains the standard technique for restoring the gastrointestinal tract following coloproctectomy for low rectal cancer. This anastomosis still requires a temporary diverting stoma to decrease the postoperative morbidity, wh...
Anastomosis Quirúrgica, Colon/cirugía, Canal Anal/cirugía, Procedimientos Quirúrgicos del Sistema Digestivo/métodos, Proctectomía
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PVP solid dispersions containing Poloxamer 407 or TPGS for the improvement of ursolic acid release

Pironi, Andressa Maria; Eloy, Josimar de Oliveira; Rodero, Camila Fernanda; Antonio, Selma Gutierrez; Alonso, Jovan Duran; Chorilli, Marlus.
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30 (PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or poloxamer 407 (P407) with the aim of enhancing solubility and in vitro release ...
Poloxámero/efectos adversos, Difusión, Microscopía Electrónica de Rastreo/métodos, Preparaciones Farmacéuticas/análisis, Rayos X/efectos adversos, Polietilenglicoles/administración & dosificación, Técnicas In Vitro, Rastreo Diferencial de Calorimetría/métodos, Solubilidad
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Short-term outcomes of laparoscopic-assisted colectomy versus open colectomy in patients with colonic carcinoma: a prospective randomized study

Baz, Yasser; Orban, Yasser A; Ezzat, Mohammed M.
J. coloproctol. (Rio J., Impr.); 43 (1), 2023
Introduction: The second most common cause of cancer-related mortality is colorectal cancer, and laparoscopic-assisted colectomy (LAC) has gained popularity among surgeons as an alternative to the conventional approach, which is open colecrtomy (OC). The differences between LAC and OC in terms of short-t...
Resultado del Tratamiento, Laparoscopía, Procedimientos Quirúrgicos del Sistema Digestivo/métodos, Neoplasias del Colon/cirugía, Pérdida de Sangre Quirúrgica, Complicaciones Posoperatorias
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Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples

Ferreira-Nunes, Ricardo; Almeida, Edson Aliel Teixeira de; Cunha-Filho, Marcilio; Gratieri, Tais; Gelfuso, Guilherme Martins.
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract n our study, we aimed to validate a method based on liquid chromatography-mass spectrometry (LC-MS) to quantify spironolactone (SPI) and its active metabolite canrenone (CAN) simultaneously in plasma samples to support in vivo experiments. Compounds were separated by using a C18 column with the ...
Cromatografía Liquida/métodos, Espectrometría de Masas/métodos, Espironolactona/análisis, Canrenona/análisis, Plasma, Farmacocinética, Antagonistas de Andrógenos/efectos adversos
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Efeitos do D-limoneno no metabolismo energético de camundongos C57/Bl6 com obesidade induzida pela dieta

Silva, Lara dos Santos Martins da.
A obesidade está associada ao desenvolvimento de doenças crônicas não transmissíveis como hipertensão, resistência insulínica, dislipidemia e esteatose hepática. O consumo de compostos bioativos impacta na manutenção da saúde e na prevenção de risco de desenvolvimento dessas doenças. Entre...
Limoneno/efectos adversos, Obesidad/inducido químicamente, Monoterpenos/análisis, Antiinflamatorios/administración & dosificación, Citrus sinensis/metabolismo, Dieta Alta en Grasa/efectos adversos, Enfermedad Crónica/clasificación, Inflamación/complicaciones, ddcs0502190, Técnicas In Vitro/métodos
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