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Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes

Hirata, Rosario Dominguez Crespo; Genvigir, Fabiana Dalla Vecchia; Hirata, Thiago Dominguez Crespo; Cerda, Alvaro; Hirata, Mario Hiroyuki.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract Mycophenolic acid (MPA) inhibits IMPDH, involved in the guanosine nucleotides synthesis, and prevents DNA replication in immune cells. The repression of cell and humoral immunity by MPA induces allograft tolerance preventing acute rejection in solid organ transplantation. MPA is an effective and...
Farmacogenética/instrumentación, Ácido Micofenólico/análisis, Trasplante de Riñón/clasificación, Inmunidad/inmunología, Preparaciones Farmacéuticas/administración & dosificación, d0230010, d0163770
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Thromboelastometry assessment of mycophenolate mofetil effect on thrombotic risk in dogs with primary and secondary immune-mediated hemolytic anemia and by Erhlichia canis infection

Gorenstein, T. G; Portilho, F. V. R; Calobrizi, N. P; Gonçalves, D. S; Paes, A. C; Takahira, R. K.
Arq. bras. med. vet. zootec. (Online); 73 (2), 2021
This study aimed to identify, by means of thromboelastometry assessment, altered thrombotic risk in dogs with primary and secondary IMHA by E. canis infection after initiating the immunosuppressive therapy with mycophenolate mofetil. The animals’ screening was based on complete blood count (CBC), bioch...
Tromboelastografía/veterinaria, Ácido Micofenólico/análisis, Ácido Micofenólico/efectos adversos, Anemia Hemolítica/complicaciones, Anemia Hemolítica/veterinaria, Inmunosupresores/uso terapéutico, Hemostasis, Ehrlichia canis, Recuento de Eritrocitos/veterinaria
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