LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Acidic Environment Induces Pyroptosis of NLRP3 Inflammatory Vesicle-Mediated Nucleus Pulposus Cells Through Up-Regulation of POSTN Expression

Zhang, Lin; Tao, Jingwen; Lu, Xiaoqin; Yu, Huaixi; Cai, Feng; Chen, Xiaogang.

Int. j. morphol; 41 (6), 2023

SUMMARY: Intervertebral disc degeneration (IVDD) is induced by nucleus pulposus (NP) dysfunction as a result of massive loss of NP cells. It has been reported that the acidic microenvironment of the intervertebral disc (IVD) can induce NP cell pyroptosis, and that up-regulation of periostin (POSTN) expre...

Ácidos/química, Ambiente, Degeneración del Disco Intervertebral, Núcleo Pulposo/fisiopatología, Moléculas de Adhesión Celular/metabolismo, Núcleo Pulposo/citología, Proteína con Dominio Pirina 3 de la Familia NLR, Ratas Sprague-Dawley, Moléculas de Adhesión Celular/genética, Reacción en Cadena en Tiempo Real de la Polimerasa, Western Blotting, Ensayo de Inmunoadsorción Enzimática, Supervivencia Celular, d0123330

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Chemical pretreatment of Arundo donax L. for second-generation ethanol production

Background: Pretreatment of lignocellulosic biomass is essential for using it as a raw material for chemical and biofuel production. This study evaluates the effects of variables in the chemical pretreatment of the Arundo biomass on the glucose and xylose concentrations in the final enzymatic hydrolysate...