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Protective effects of sodium ferulate on flap transplantation via anti-inflammatory modulation and oxidative stress inhibition

Sun, Y D; Gao, Y S; Xu, L W; Zhang, Y F; Cheng, C; Wei, K C; Lin, Jian; Chen, G; Liu, C Y; Li, Q F.
Braz. j. med. biol. res; 54 (7), 2021
Ischemia-reperfusion injury (IRI) has brought attention to flap failure in reconstructive surgery. To improve the prognosis of skin transplantation, we performed experimental IRI by surgical obstruction of blood flow and used sodium ferulate (SF) to prevent IRI in rats. After SF treatment, the morphologi...
Antiinflamatorios/farmacología, Ácidos Cumáricos/farmacología, Estrés Oxidativo, Daño por Reperfusión/tratamiento farmacológico, Daño por Reperfusión/prevención & control
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Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity

de Melo, TS; Lima, PR; Carvalho, KMMB; Fontenele, TM; Solon, FRN; Tomé, AR; de Lemos, TLG; da Cruz Fonseca, SG; Santos, FA; Rao, VS; de Queiroz, MGR.
Braz. j. med. biol. res; 50 (1), 2017
Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity ...
Tejido Adiposo/patología, Fármacos Antiobesidad/farmacología, Ácidos Cumáricos/farmacología, Ciclobutanos/farmacología, Dieta Alta en Grasa, Modelos Animales de Enfermedad, Grasa Intraabdominal/efectos de los fármacos, Obesidad/tratamiento farmacológico, Obesidad/patología
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A stability-indicating HPLC-PDA method for the determination of ferulic acid in chitosan-coated poly(lactide-co-glycolide) nanoparticles

Lima, Isabela Angeli de; Khalil, Najeh Maissar; Mainardes, Rubiana Mara.
Braz. J. Pharm. Sci. (Online); 53 (2), 2017
ABSTRACT The development and validation of a simple and efficient method for the quantification of ferulic acid in poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan (CS) by reverse phase high performance liquid chromatography coupled to photodiode array detection was described. Fo...
Cromatografía Líquida de Alta Presión/métodos, Nanopartículas/clasificación, Quitosano/farmacología, Antioxidantes/clasificación, Ácidos Cumáricos/farmacología, Estudio de Validación
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