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Free fatty acids reduce metabolic stress and favor a stable production of heterologous proteins in Pichia pastoris

Zepeda, Andrea B; Figueroa, Carolina A; Pessoa, Adalberto; Farías, Jorge G.
Braz. j. microbiol; 49 (4), 2018
ABSTRACT The growth of yeasts in culture media can be affected by many factors. For example, methanol can be metabolized by other pathways to produce ethanol, which acts as an inhibitor of the heterologous protein production pathway; oxygen concentration can generate aerobic or anaerobic environments and...
Medios de Cultivo/química, Medios de Cultivo/metabolismo, Ácidos Grasos no Esterificados/metabolismo, Fermentación, Glicerol/metabolismo, Metanol/metabolismo, Pichia/genética, Pichia/crecimiento & desarrollo, Pichia/metabolismo, Proteínas Recombinantes/genética, Temperatura
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Free fatty acids (FFA) and type II diabetes

Wajchenberg, Fernado Léo; Santomauro, Ana Tereza M. G.
Arq. bras. endocrinol. metab; 40 (4), 1996
Clinical and experimental data indicate that there is an increase in plasma FFA levels in type II diabetes. Despite the enhanced lipolysis all evidences suggested no rate of entry of FFA into plasma, implying a compensatory increase in re-esterification of FFA liberated from adipose tissue, a reduced cle...
Ácidos Grasos no Esterificados/metabolismo, Insulina/22063

Distúrbios do metabolismo mitocondrial e suas implicaçöes para o aparelho locomotor e o coraçäo: parte I
Mitochondrial metabolism disorders and their implications for the locomotor system and heart: Part I

Marchiori, Paulo Eurípedes; Gauditano, Giancarla; Mendonça, Laís Lage Furtado de; Scaff, Milberto; Ramires, José Antonio Franchini.
Arq. bras. cardiol; 52 (4), 1989
Mitocondrias/metabolismo, Errores Innatos del Metabolismo/metabolismo, Mitocondrias Musculares/metabolismo, Carbohidratos/metabolismo, ADN Mitocondrial, Carnitina/deficiencia, Acetilcoenzima A/biosíntesis, Ácidos Grasos no Esterificados/metabolismo
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