Induction of brain injury and depression in rats by chronic unpredictable stress associated with the augmentation of nitrosative stress and apoptosis
Int. j. morphol; 38 (5), 2020
SUMMARY: Repeated stress is a risk factor for memory impairment and neurological abnormalities in both humans and animals. We sought to investigate the extent of (i) brain tissue injury; (ii) nitrosative and oxidative stress in brain tissue homogenates; (iii) apoptotic and survival biomarkers in brain ti...
Estrés Psicológico/complicaciones, Enfermedad Crónica, Daño Encefálico Crónico/patología, Apoptosis, Estrés Nitrosativo, Estrés Oxidativo, Modelos Animales de Enfermedad, Ratas Wistar, Depresión, Lesiones Encefálicas/metabolismo, Óxido Nítrico Sintasa/análisis, Malondialdehído/análisis, Superóxido Dismutasa/análisis, Caspasa 3/análisis, Proteínas Proto-Oncogénicas c-bcl-2, Análisis de Varianza, Conducta Animal, Biomarcadores, Corteza Cerebral