Abstract Objective: To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups. Methods: A total of 208 ...
Fernández-Rodarte, Bernardo A;
Soto-Domínguez, Adolfo;
González-Navarro, Alejandro;
Mellado-Ayala, Maximiliano;
Piña-Mendoza, Edgar I;
Rodríguez-Rocha, Humberto;
Montes-de-Oca-Luna, Roberto;
Guerra-Leal, Jesús D;
Guzmán-López, Santos;
Elizondo-Omaña, Rodrigo E.
SUMMARY: Reactive Oxygen Species (ROS) are part of the functional balance of various systems, they can generate cellular damage by oxidative stress associated with disease processes such as atherosclerosis, cardiovascular disease, diabetes, and aging. Some studies report that copper induces damage to the...
Resumo Fundamento As células progenitoras endoteliais (CPEs) desempenham um papel importante na manutenção da função endotelial. A síndrome metabólica (SM) está associada à disfunção das CPEs. Embora o exercício físico tenha um impacto benéfico na atividade das CPEs, seu mecanismo ainda n...
BACKGROUND: Osteoporosis attacks approximately 10% of the population worldwide. Sika Deer (Cervus nippon), one of China’s precious traditional medicinal animals, has been widely recorded in ancient Chinese medical books and claimed for centuries to have numerous medical benefits including bone strength...
ABSTRACT Purpose: To assess the biochemical, histological, histomorphometric and molecular effects of biliary duct ligation (BDL) induced liver cirrhosis in the heart and kidneys. Methods: Thirty-two weaning rats (21 days old, 50-70 g) underwent BDL and were divided in four groups (euthanasia after two...
SUMMARY AIM The aim of this study was to examine the roles of nitric oxide (NOx), endothelial nitric oxide synthetase (eNOS), and asymmetric dimethylarginine (ADMA), which is the major endogenous inhibitor of nitric oxide synthases (NOS), in the pathophysiology of hemorrhoidal disease. METHODS This s...
Abstract Background: Despite increase in survival of human immunodeficiency virus (HIV) patients due to highly active antiretroviral therapy, non-infectious complications are still prevalent such as presentation of lung vasculopathy, even in asymptomatic patients. Endothelial nitric oxide synthase (eNOS...
Chemerin is an adipokine that has been associated with components of metabolic syndrome. It has been described to affect adipocyte metabolism and inflammatory responses in adipose tissue, as well as the systemic metabolism of lipids and glucose. Few epidemiological studies have evaluated classical and ge...
Apolipoproteínas B/genética,
Brasil,
Enfermedades Cardiovasculares/genética,
Enfermedades Cardiovasculares/metabolismo,
Quimiocinas/sangre,
Quimiocinas/genética,
Estudios Transversales,
Genotipo,
Óxido Nítrico Sintasa de Tipo III/genética,
Polimorfismo de Nucleótido Simple/genética,
Factores de Riesgo,
Población Rural
Abstract Objective We examined the interaction of polymorphisms in the genes heme oxygenase- 1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NO...
Abstract Purpose To reveal the function of miR-134 in myocardial ischemia. Methods Real-time PCR and western blotting were performed to measure the expression of miR-134, nitric oxide synthase 3 (NOS3) and apoptotic-associated proteins. Lactic dehydrogenase (LDH) assay, cell counting kit-8 (CCK-8), Hoe...
Apoptosis/efectos de los fármacos,
Apoptosis/fisiología,
Proliferación Celular/efectos de los fármacos,
MicroARNs/genética,
Hipoxia/metabolismo,
MicroARNs/metabolismo,
MicroARNs/uso terapéutico,
Daño por Reperfusión Miocárdica/tratamiento farmacológico,
Daño por Reperfusión Miocárdica/genética,
Daño por Reperfusión Miocárdica/metabolismo,
Daño por Reperfusión Miocárdica/patología,
Óxido Nítrico Sintasa de Tipo III/genética,
Óxido Nítrico Sintasa de Tipo III/metabolismo,
Óxido Nítrico Sintasa de Tipo III/uso terapéutico,
Fosfatidilinositol 3-Quinasas/metabolismo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Transducción de Señal/efectos de los fármacos
