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Experimental carcinogenesis with 7, 12-dimethylbenz(a)anthrazene (DMBA) and its inhibition with isothi-ocyanates

Morales-Herrero, María; Ortega-Medina, Isicio.
J. oral res. (Impresa); 11 (4), 2022
Introduction: DMBA is a chemical carcinogen that induces carcinomas within a few weeks of its application. We developed an experimental model of carcinogenesis induced by DMBA dissolved in 0,5% paraffin oil (DMBA-PO), verifying the inhibitory effect of the carcinogenicity of phenyl isothiocyanate (PhITC)...
9,10-Dimetil-1,2-benzantraceno/toxicidad, Anticarcinógenos/uso terapéutico, Carcinoma de Células Escamosas de Cabeza y Cuello, Isotiocianatos, Carcinogénesis, Carcinógenos, Modelos Animales
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Relationship between the toxicity of raw Annona muricata leaves extract and 7, 12-dimethylbenzathracene (DMBA) with histopathological changes in wistar rats

Splendor, Maria Clara; Kaneshima, Alice Maria de Souza; Becker, Tania Cristina Alexandrino; Mello, Joao Carlos Palazzo de; Souza, Paola da Costa; Pedroso, Raíssa Bocchi; Pelegrini, Brenda Barroso; Kaneshima, Edilson Nobuyoshi.
Acta toxicol. argent; 30 (1), 2022
Abstract Aims: To identify the histopathological alterations in organs of Wistar rats to evaluate toxic effects of use of Annonamuricata Raw Leaf Extract (AMRLE) alone or in association with DMBA. Settings and Design: Sixty female Wistar rats were used, separated into groups and treated with a single dos...
Annona/toxicidad, Annona/efectos adversos, 9,10-Dimetil-1,2-benzantraceno/toxicidad, Extractos Vegetales/toxicidad, Ratas Wistar
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