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Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation

Xu, Sha; Xiong, Jun; Wu, Minjuan; Yang, Yu; Jiang, Junfeng; Ni, Haitao; Zhao, Yunpeng; Wang, Yue.
Braz. j. med. biol. res; 54 (2), 2021
Severe blockage in myeloid differentiation is the hallmark of acute myeloid leukemia (AML). Trdmt1 plays an important role in hematopoiesis. However, little is known about the function of Trdmt1 in AML cell differentiation. In the present study, Trdmt1 was up-regulated and miR-181a was down-regulated sig...
ADN (Citosina-5-)-Metiltransferasas/genética, Diferenciación Celular, Células HL-60, Leucemia Mieloide Aguda/genética, MicroARNs/genética
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miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis

Coêlho, Marina Castro; Queiroz, Ingrid Costa; Viana Filho, José Maria Chagas; Aquino, Sabrina Garcia de; Persuhn, Darlene Camati; Oliveira, Naila Francis Paulo de.
J. appl. oral sci; 28 (), 2020
Abstract Genetic and epigenetic changes have been associated with periodontitis in various genes; however, little is known about genes involved in epigenetic mechanisms and in oxidative stress. Objective: This study aims to investigate the association of polymorphisms C677T in MTHFR (rs1801133) and W...
Estudios de Casos y Controles, Catalasa/genética, ADN (Citosina-5-)-Metiltransferasas/genética, Metilación de ADN/genética, Estudios de Asociación Genética, Genotipo, Metilenotetrahidrofolato Reductasa (NADPH2)/genética, MicroARNs/genética, Periodontitis/genética, Reacción en Cadena de la Polimerasa, Polimorfismo Genético, Polimorfismo de Longitud del Fragmento de Restricción, Superóxido Dismutasa-1/genética
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