LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Cerebrospinal fluid challenges for the diagnosis of herpes simplex infection in the central nervous system

Da Silva, Samya Jezine; Cabral-Castro, Mauro Jorge; Guimarães, Maria Angélica; Peralta, José Mauro; Puccioni-Sohler, Marzia.

Arq. neuropsiquiatr; 78 (3), 2020

Abstract Herpes simplex virus (HSV) is a cause of a severe disease of the central nervous system (CNS) in humans. The demonstration of specific antibodies in the cerebrospinal fluid (CSF) may contribute to the retrospective neurological diagnosis. However, the commercial immunological tests for HSV infec...

Anticuerpos Antivirales/líquido cefalorraquídeo, Líquido Cefalorraquídeo/virología, ADN Viral/genética, ADN Polimerasa Dirigida por ADN/genética, Exodesoxirribonucleasas, Herpes Simple/líquido cefalorraquídeo, Herpes Simple/diagnóstico, Herpes Simple/virología, Sistema Nervioso, Reacción en Cadena de la Polimerasa/métodos, Estudios Retrospectivos, Simplexvirus/genética, Simplexvirus/aislamiento & purificación, Proteínas Virales

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Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China

Abstract Objective There are a lot of disagreements in the studies on hepatitis B virus (HBV) DNA polymerase mutation rate associated with nucleos(t)ide analogues (NAs) in treatment-naive chronic hepatitis B (CHB) patients. This is the first study aimed to investigate the prevalence of spontaneous HBV r...