BACKGROUND: Atherosclerosis (AS) is the most common type in cardiovascular disease. Due to its complex pathogenesis, the exact etiology of AS is unclear. circRNA has been shown to play an essential role in most diseases. However, the underlying mechanism of circRNA in AS has been not understood clearly. ...
Aterosclerosis/genética,
MicroARNs/genética,
Apoptosis/genética,
Histona Desacetilasa 1/genética,
Proliferación Celular,
Células Endoteliales de la Vena Umbilical Humana,
Inflamación/genética,
Lipoproteínas LDL,
Proteínas Nucleares,
ARN Circular,
Transactivadores
BACKGROUND: Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). METHODS: High-throughput sequencing was used to collect the plasma circRNAs expression pr...
Recently, an increasing number of studies have reported that dysregulation of circular RNA (circRNA) expression plays critical roles in the progression of several cancers, including colorectal cancer (CRC). However, the detailed molecular mechanisms of circRNAs involvement in CRC remain largely unknown. ...
The aim of this study was to explore the effect of hsa_circ_0002162 on regulating cell proliferation, apoptosis, and invasion, and investigate its potential target microRNA (miRNA) in tongue squamous cell carcinoma (TSCC). Hsa_circ_0002162 expression was detected in human TSCC cell lines and human oral k...
Jiang, Su;
Zhao, Gaonian;
Lu, Jun;
Jiang, Min;
Wu, Zhenggang;
Huang, Yujing;
Huang, Jing;
Shi, Jinghua;
Jin, Jing;
Xu, Xinxuan;
Pu, Xuehua.
BACKGROUND: Circular RNA (circRNA) is highly expressed in the brain tissue, but its molecular mechanism in cerebral ischemia-reperfusion remains unclear. Here, we explored the role and underlying mechanisms of circRNA antisense non-coding RNA in the INK4 locus (circ_ANRIL) in oxygen-glucose deprivation a...
Hipoxia Encefálica/metabolismo,
MicroARNs/genética,
MicroARNs/fisiología,
Daño por Reperfusión/metabolismo,
ARN Circular,
Apoptosis,
Encéfalo,
Inhibidor p16 de la Quinasa Dependiente de Ciclina,
Células Endoteliales,
Glucosa/metabolismo,
Inflamación,
Oxígeno,
ARN Largo no Codificante
Sun, Ying;
Wang, Wei;
Tang, Yuxiao;
Wang, Daping;
Li, Liang;
Na, Min;
Jiang, Guantong;
Li, Qian;
Chen, Shulin;
Zhou, Jin.
BACKGROUND: Circulating RNA (circRNA) regulates various bioactivities in cells. A better understanding of the exosomal circRNA can provide novel insights into the pathogenesis and treatment of Graves' disease (GD). We aimed to profile the differentially expressed circRNAs (DEcRs) in plasma exosomes of pa...
Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of life of patients. However, epigenetic mechanisms involved in the development of osteoporosis rem...
BACKGROUND: Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal cord injury (SCI) to uncover the molecular mechanisms of anti-inflammation. RESULTS: HIF-1α was reduced in SCI model rats and HIF-1α activa...
Yin, Ronghuan;
Wang, Yanru;
Wang, Zeying;
Zhu, Yubo;
Cong, Yuyan;
Wang, Wei;
Deng, Liang;
Liu, Haiying;
Guo, Dan;
Bai, Wenlin.
Background: Circular RNAs, a novel class in the eukaryotic transcriptome, are characterized by the 3′ and 5′ ends that are covalently joined in a covalently closed loop without free ends. Circular RNAs are considerably stable molecules and act as microRNA sponges with regulatory potential to the prot...
Cabras/genética,
Folículo Piloso/crecimiento & desarrollo,
ARN Circular/genética,
ARN Circular/metabolismo,
MicroARNs,
Biología Computacional,
Piel,
Redes Reguladoras de Genes,
Transcriptoma,
Células Eucariotas,
Expresión Génica
BACKGROUND: Recent studies indicate that circular RNAs (circRNAs) may play important roles in the regulation of plant growth and development. Plant roots are the main organs of nutrient and water uptake. However, whether circRNAs involved in the regulation of plant root growth remains to be elucidated. ...
