Bendelman, Gisela;
Carretero, Marcelina;
Pérez de Arenaza, Diego;
Villanueva, Eugenia;
Brulc, Erika B;
Nucifora, Elsa M;
Marco, María A;
Sáez, María S;
Sorroche, Patricia B;
Aguirre, María A;
Posadas Martínez, María L.
La amiloidosis por depósito de transtiretina es una enfermedad infrecuente y se debe al depósito de fibrillas de dicha proteína en diversos tejidos, aunque la afectación más frecuente es la cardíaca y la neurológica. Puede ser adquirida (antiguamente llamada “amiloidosis senil”...
SUMMARY: This study is to investigate the effect of survivin down-regulation by Egr1-survivin shRNA combined with radiotherapy on the apoptosis and radiosensitivity of esophageal squamous cell carcinoma ECA109 and KYSE150 cells. ECA109 and KYSE150 cells were transfected with Egr1-survivin shRNA, and then...
Neoplasias Esofágicas/terapia,
Carcinoma de Células Escamosas de Esófago/terapia,
Neoplasias Esofágicas/genética,
Carcinoma de Células Escamosas de Esófago/genética,
Transfección,
Survivin,
Fármacos Sensibilizantes a Radiaciones,
Neoplasias Esofágicas/radioterapia,
Carcinoma de Células Escamosas de Esófago/radioterapia,
Línea Celular Tumoral/efectos de la radiación,
ARN Mensajero,
Western Blotting,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación hacia Abajo,
Apoptosis,
Citometría de Flujo,
Caspasa 3,
Caspasa 9,
ARN Interferente Pequeño,
Terapia Combinada,
Tolerancia a Radiación,
Proteína 1 de la Respuesta de Crecimiento Precoz
Abstract The aim of the present study was to investigate the effect of swertiamarin (STM) in attenuating paraquat (PQ)-induced human lung alveolar epithelial-like cell (A549) apoptosis and the underlying mechanisms. A549 cells were pretreated with different concentrations of STM for 2 hr and then culture...
Abstract Vascular endothelial growth factor (VEGF) is an essential angiogenic factor in breast cancer development and metastasis. Small interfering RNAs (siRNAs) can specifically silence genes via the RNA interference pathway, therefore were investigated as cancer therapeutics. In this study, we investig...
Cui, Xinyuan;
Li, Yifu;
Yuan, Shuguang;
Huang, Yao;
Chen, Xiaojun;
Han, Yachun;
Liu, Zhiwen;
Li, Zheng;
Xiao, Yang;
Wang, Youliang;
Sun, Lin;
Liu, Hong;
Zhu, Xuejing.
BACKGROUND: Alpha-kinase 1 (ALPK1) is a master regulator in inflammation and has been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic nephropathy (DN) mice. Pyroptosis is involved in high glucose (HG)-induced tubular cells injury, characterized by activation of Gasdermi...
Abstract Background: Glutamate and voltage-gated sodium channels, both have been the target of intense investigation for its involvement in carcinogenesis and progression of malignant disease. Breast cancer with increased level of glutamate often metastasize to other organs (especially bone), whilst re-e...
ABSTRACT Background: Acute hepatic porphyrias represent an expanding group of complex inherited metabolic disorders due to inborn errors of metabolism involving heme biosynthesis. Objective: We aimed to review the main clinical and therapeutic aspects associated with acute hepatic porphyrias. Methods:...
The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ect...
ABSTRACT Objective To evaluate the effects of Arf6 downregulation on human prostate cancer cells. Materials and Methods The effects of Arf6 downregulation on cell proliferation, migration, invasion and apoptosis were assessed by MTT, BrdU, scratch, Transwell assays and flow cytometry respectively. AK...
Introducción: El SARS-CoV-2 es el agente causal de la COVID-19, enfermedad respiratoria que ha causado miles de víctimas fatales a escala global, y para la cual no existe ninguna terapia curativa efectiva. Objetivo: Reflejar la relevancia potencial de la tecnología de ARN de interferencia (ARNi), com...
