SUMMARY: Overexpression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in various tumor tissues and cell lines was found to promote tumor cell proliferation, migration, and invasion. However, the role of MALAT1 in gastric cancer (GC) is still unclear. We aimed to investigate the corre...
Neoplasias Gástricas/patología,
ARN Largo no Codificante,
Proliferación Celular,
Factor A de Crecimiento Endotelial Vascular,
Serina-Treonina Quinasas TOR,
Transducción de Señal,
Neoplasias Gástricas/genética,
ARN/genética,
Western Blotting,
Genes Reporteros,
Invasividad Neoplásica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación Neoplásica de la Expresión Génica,
Movimiento Celular,
Apoptosis
Purpose: Colorectal cancer (CRC) is one of the most fatal tumors worldwide. In Egypt, most CRC cases occur in individuals > 40 years old. TUG1 has been proved to be disrupted in different malignancies and may have a critical role in tumor progression, invasion, and metastasis. However, its role in CRC ha...
Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, it is necessary to assess the molecular mechanisms involved in cell cycle regulation in tumor ce...
BACKGROUND: The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells. Acupuncture has been shown to improve follicular development abnormalities in patients with PCOS, but its me...
Colorectal cancer (CRC) is the third most prevalent cancer and the second most common cause of cancer death; however, its early detection can improve the survival. Colonic polyps are considered one of the CRC's major risk factors. Throughout many biological processes and malignancies, the non-coding RNAs...
SUMMARY OBJECTIVE: A growing volume of literature has suggested long noncoding RNAs (lncRNAs) as important players in tumor progression. In this study, we aimed to investigate the expression and prognostic value of lncRNA LINC00173 (LINC00173) in melanoma. METHODS: LINC00173 expression was measured in ...
Colorectal cancer is the 4thcause of cancer death; with considering the growth process of this cancer and the necessity of early diagnosis, the purpose of the research is to state the LncRNA 00970, LncRNA UCAI,and the Wntgene before and after the treatment by 5-Azacytidine epigenetic medi...
Técnicas In Vitro/métodos,
Azacitidina/análisis,
Biomarcadores,
ADN/análisis,
Diagnóstico Precoz,
Neoplasias Colorrectales/tratamiento farmacológico,
ARN Largo no Codificante/efectos de los fármacos,
Genes,
Epigenómica,
Línea Celular/efectos de los fármacos,
Neoplasias del Colon/diagnóstico,
Azacitidina/antagonistas & inhibidores,
Neoplasias Colorrectales/mortalidad,
Neoplasias Colorrectales/terapia,
ARN Largo no Codificante,
Neoplasias del Colon/tratamiento farmacológico,
Neoplasias del Colon/terapia
SUMMARY OBJECTIVE: Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Previous studies have indicated the involvement of vitamin D receptor (VDR) and related long noncoding RNAs (lncRNAs) signaling in the pathophysiology of several cancers. However, their contribution to ALL...
