LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

lncRNA ZEB1-AS1 inhibits high glucose-induced EMT and fibrogenesis by regulating the miR-216a-5p/BMP7 axis in diabetic nephropathy

Meng, Qingqing; Zhai, Xiaolin; Yuan, Yi; Ji, Qing; Zhang, Pengyuan.

Braz. j. med. biol. res; 53 (4), 2020

Diabetic nephropathy (DN) is one of the leading causes of mortality in diabetic patients. Long non-coding RNA zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) plays a crucial role in the development of various diseases, including DN. However, the molecular mechanism of ZEB1-AS1 in DN pathogene...

Proteína Morfogenética Ósea 7/metabolismo, Células Cultivadas, Nefropatías Diabéticas/genética, Nefropatías Diabéticas/metabolismo, Regulación hacia Abajo, Transición Epitelial-Mesenquimal/fisiología, MicroARNs/metabolismo, ARN Largo no Codificante/fisiología, Reacción en Cadena en Tiempo Real de la Polimerasa, Regulación hacia Arriba, Homeobox 1 de Unión a la E-Box con Dedos de Zinc/metabolismo

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LncRNA OIP5-AS1 upregulates snail expression by sponging miR-34a to promote ovarian carcinoma cell invasion and migration

Jiang, Xingzhi; Ye, Zhongxue; Jiang, Yafen; Yu, Wen; Fang, Qian.

Biol. Res; 53 (), 2020

BACKGROUND: Although OIP5-AS1 has been characterized as an oncogenic lncRNA in many types of cancer, its role and underlying mechanism in ovarian carcinoma (OC) remains unknown. This study aimed to investigate the role of OIP5-AS1 in OC. METHODS: OC tissues and non-tumor tissues (ovary tissues within 3 c...

MicroARNs/genética, MicroARNs/metabolismo, Neoplasias Ováricas/genética, Neoplasias Ováricas/patología, ARN Largo no Codificante/genética, ARN Largo no Codificante/fisiología, Proliferación Celular, Regulación Neoplásica de la Expresión Génica, Invasividad Neoplásica

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Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells

Rui, Qiu Hong; Ma, Jian Bo; Liao, Yu Feng; Dai, Jin Hua; Cai, Zhen Yu.

Braz. j. med. biol. res; 52 (4), 2019

Pituitary adenoma is one of the most common tumors in the neuroendocrine system. This study investigated the effects of long non-coding RNAs (lncRNAs) highly up-regulated in liver cancer (HULC) on rat secreting pituitary adenoma GH3 cell viability, migration, invasion, apoptosis, and hormone secretion, a...

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Role of non-coding RNAs in non-aging-related neurological disorders

Vieira, A S; Dogini, D B; Lopes-Cendes, I.

Braz. j. med. biol. res; 51 (8), 2018

Protein coding sequences represent only 2% of the human genome. Recent advances have demonstrated that a significant portion of the genome is actively transcribed as non-coding RNA molecules. These non-coding RNAs are emerging as key players in the regulation of biological processes, and act as "fine-tun...

MicroARN Circulante, Regulación de la Expresión Génica, Marcadores Genéticos/fisiología, MicroARNs/fisiología, Enfermedades del Sistema Nervioso/genética, Enfermedades Neurodegenerativas/genética, Enfermedades Neuromusculares/genética, ARN Largo no Codificante/fisiología

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Long non-coding RNA CHCHD4P4 promotes epithelial-mesenchymal transition and inhibits cell proliferation in calcium oxalate-induced kidney damage

Zhang, C; Yuan, J; Hu, H; Chen, W; Liu, M; Zhang, J; Sun, S; Guo, Z.

Braz. j. med. biol. res; 51 (1), 2018

Kidney stone disease is a major cause of chronic renal insufficiency. The role of long non-coding RNAs (lncRNAs) in calcium oxalate-induced kidney damage is unclear. Therefore, we aimed to explore the roles of lncRNAs in glyoxylate-exposed and healthy mouse kidneys using microarray technology and bioinfo...

Western Blotting, Oxalato de Calcio, Fraccionamiento Celular, Línea Celular, Proliferación Celular/genética, Proliferación Celular/fisiología, Transición Epitelial-Mesenquimal/genética, Transición Epitelial-Mesenquimal/fisiología, Fibrosis, Cálculos Renales/genética, Cálculos Renales/fisiopatología, Análisis por Micromatrices, Proteínas de Transporte de Membrana Mitocondrial/fisiología, ARN Largo no Codificante/fisiología, Reacción en Cadena en Tiempo Real de la Polimerasa, Regulación hacia Arriba

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Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy

Wang, Z K; Yang, L; Wu, L L; Mao, H; Zhou, Y H; Zhang, P F; Dai, G H.

Braz. j. med. biol. res; 51 (2), 2018

Colon cancer is one of the most common digestive tumors. The present study aimed to explore the functional role, as well as the underlying mechanism of long non-coding RNA LINC00261 in colon cancer. Expression of LINC00261 was analyzed in colon cancer cell lines and human normal cell lines. Acquired resi...

Análisis de Varianza, Antineoplásicos/farmacología, Apoptosis/efectos de los fármacos, Apoptosis/fisiología, Proteínas Reguladoras de la Apoptosis/efectos de los fármacos, Western Blotting, Ensayos de Migración Celular, Regulación hacia Abajo, ARN Largo no Codificante/fisiología, Reproducibilidad de los Resultados, Sales de Tetrazolio, Tiazoles, beta Catenina/fisiología

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LncRNA SNHG12 promotes cell growth and inhibits cell apoptosis in colorectal cancer cells

Wang, JZ; Xu, CL; Wu, H; Shen, SJ.

Braz. j. med. biol. res; 50 (3), 2017

Several long non-coding RNA (lncRNA) might be correlated with the prognosis of colorectal cancer (CRC) and serve as a diagnostic and prognostic biomarker. However, the exact expression pattern of small nucleolar RNA host gene 12 (SNHG12) in colorectal cancer and its clinical significance remains unclear....

Apoptosis, Western Blotting, Proliferación Celular/fisiología, Neoplasias Colorrectales/metabolismo, Citometría de Flujo, Regulación Neoplásica de la Expresión Génica, ARN Largo no Codificante/fisiología, Reacción en Cadena en Tiempo Real de la Polimerasa, Regulación hacia Arriba

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