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Results: 44

Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis

Zangouei, Amir Sadra; Zangoue, Malihe; Taghehchian, Negin; Zangooie, Alireza; Reza Rahimi, Hamid; Saburi, Ehsan; Sadat Alavi, Mahya; Moghbeli, Meysam.
Biol. Res; 56 (), 2023
Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, it is necessary to assess the molecular mechanisms involved in cell cycle regulation in tumor ce...
Neoplasias de la Mama/diagnóstico, Neoplasias de la Mama/genética, Neoplasias de la Mama/patología, ARN Largo no Codificante/genética, ARN Largo no Codificante/metabolismo, Ciclo Celular/genética, Puntos de Control del Ciclo Celular, División Celular
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Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma

Wang, Mujun; Liu, Wei; Liu, Wenxing; Wang, Chao.
Rev. Assoc. Med. Bras. (1992, Impr.); 68 (2), 2022
SUMMARY OBJECTIVE: A growing volume of literature has suggested long noncoding RNAs (lncRNAs) as important players in tumor progression. In this study, we aimed to investigate the expression and prognostic value of lncRNA LINC00173 (LINC00173) in melanoma. METHODS: LINC00173 expression was measured in ...
Biomarcadores de Tumor/genética, Regulación Neoplásica de la Expresión Génica, Estimación de Kaplan-Meier, Melanoma/diagnóstico, Melanoma/genética, Pronóstico, ARN Largo no Codificante/genética, ARN Largo no Codificante/metabolismo
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Exploring the expression profile of vitamin D receptor and its related long non-coding RNAs in patients with acute lymphoblastic leukemia

Norouzi, Akram; Motaghi, Marzieh; Hassanshahi, Gholamhossein; Nazari-Robati, Mahdieh.
Rev. Assoc. Med. Bras. (1992); 67 (8), 2021
SUMMARY OBJECTIVE: Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Previous studies have indicated the involvement of vitamin D receptor (VDR) and related long noncoding RNAs (lncRNAs) signaling in the pathophysiology of several cancers. However, their contribution to ALL...
Estudios de Casos y Controles, Leucemia-Linfoma Linfoblástico de Células Precursoras/genética, ARN Largo no Codificante/genética, Receptores de Calcitriol/genética, Vitamina D
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Long non-coding ribonucleic acid H19 and ten-eleven translocation enzyme 1 messenger RNA expression levels in uterine fibroids may predict their postoperative recurrence

Zhan, Xiangjuan; Zhou, Hui; Sun, Yuhong; Shen, Baomei; Chou, Di.
Clinics; 76 (), 2021
OBJECTIVES: To investigate the predictive value of long non-coding RNA (lncRNA) H19 and the ten-eleven translocation enzyme 1 (TET1) transcriptional expression in postoperative recurrence of uterine fibroids (UFs). METHODS: Seventy-five patients with UF, who underwent surgical treatment, were enrolled i...
Leiomioma, Oxigenasas de Función Mixta, Recurrencia Local de Neoplasia, Proteínas Proto-Oncogénicas, ARN Largo no Codificante/genética, ARN Mensajero, Curva ROC
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A novel lncRNA-mRNA-miRNA signature predicts recurrence and disease-free survival in cervical cancer

Li, Mengxiong; Tian, Xiaohui; Guo, Hongling; Xu, Xiaoyu; Liu, Yun; Hao, Xiulan; Fei, Hui.
Braz. j. med. biol. res; 54 (11), 2021
Cervical cancer (CC) patients have a poor prognosis due to the high recurrence rate. However, there are still no effective molecular signatures to predict the recurrence and survival rates for CC patients. Here, we aimed to identify a novel signature based on three types of RNAs [messenger RNA (mRNAs), m...
Supervivencia sin Enfermedad, Regulación Neoplásica de la Expresión Génica, MicroARNs/genética, Recurrencia Local de Neoplasia/genética, ARN Largo no Codificante/genética, ARN Mensajero, Ubiquitina-Proteína Ligasas, Neoplasias del Cuello Uterino/genética, Proteínas de Unión al GTP rab
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Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro

Farfán, Nicole; Sanhueza, Nicole; Briones, Macarena; Burzio, Luis O; Burzio, Verónica A.
Biol. Res; 54 (), 2021
BACKGROUND: The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, apoptosis and invasiveness reduction in tumor but not normal cells. One of these tra...
MicroARNs/genética, ARN Largo no Codificante/genética, Línea Celular Tumoral, Proliferación Celular, Regulación Neoplásica de la Expresión Génica, ARN sin Sentido/genética, ARN Mitocondrial/genética
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Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model

Lv, Kefeng; Liu, Yuhua; Zheng, Yanbing; Dai, Shaowen; Yin, Peifeng; Miao, Haifeng.
Biol. Res; 54 (), 2021
BACKGROUNDS: Parkinson's disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in PD. METHODS: SK-N-SH and SK-N-BE cells were tr...
Glicoproteínas de Membrana/genética, MicroARNs/genética, Enfermedad de Parkinson/genética, ARN Largo no Codificante/genética, Apoptosis, Proliferación Celular, Células Cultivadas
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LncRNA MALAT1 aggravates oxygen-glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis

Jia, Ying; Yi, Lian; Li, Qianqian; Liu, Tingjiao; Yang, Shanshan.
Biol. Res; 54 (), 2021
BACKGROUND: This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury. RESULTS: Using an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model, we determined that the e...
Adenocarcinoma del Pulmón, Neoplasias Pulmonares, MicroARNs/genética, ARN Largo no Codificante/genética, Daño por Reperfusión/genética, Apoptosis/genética, Estrés del Retículo Endoplásmico/genética, Glucosa, Proteína HMGA1a, Oxígeno
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