Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, it is necessary to assess the molecular mechanisms involved in cell cycle regulation in tumor ce...
SUMMARY OBJECTIVE: A growing volume of literature has suggested long noncoding RNAs (lncRNAs) as important players in tumor progression. In this study, we aimed to investigate the expression and prognostic value of lncRNA LINC00173 (LINC00173) in melanoma. METHODS: LINC00173 expression was measured in ...
Yin, Rong H;
Wang, Yan R;
Zhao, Su J;
Yin, Rong L;
Bai, Man;
Wang, Ze Y;
Zhu, Yu B;
Cong, Yu Y;
Liu, Hai Y;
Bai, Wen L.
BACKGROUND:
Long non-coding RNAs (lncRNAs), as post-transcriptional regulators, were thought to function in the inductive property of dermal papilla cells (DPCs) in cashmere goat. Previously, lncRNA-599554 was identified in secondary hair follicle (SHF) of cashmere goat, but its functional significance i...
Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is one kind of cytoplasmic long non-coding RNA (lncRNA), which has been demonstrated to play a critical function in multiple cancers. However, the detailed mechanism of OIP5-AS1 in the regulation of cervical cancer progression is still obscure. ...
Apoptosis/genética,
Apoptosis/fisiología,
Western Blotting,
Línea Celular Tumoral,
Proliferación Celular/genética,
Proliferación Celular/fisiología,
Regulación Neoplásica de la Expresión Génica,
MicroARNs/genética,
MicroARNs/metabolismo,
ARN Largo no Codificante/genética,
ARN Largo no Codificante/metabolismo,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Regulación hacia Arriba,
Neoplasias del Cuello Uterino/metabolismo,
Neoplasias del Cuello Uterino/patología,
Quinasas Asociadas a rho/genética,
Quinasas Asociadas a rho/metabolismo
SUMMARY OBJECTIVE Long noncoding RNA neuroblastoma-associated transcript 1 (NBAT1) has been reported to be involved in cancer progression. However, the clinical significance of NBAT1 in non-small cell lung cancer (NSCLC) is still unclear. Our present research aimed to explore whether NBAT1 serves as a ...
BACKGROUND: Long non-coding RNA small molecule RNA host gene 1 (SNHG1) was previously identified to be relevant with Parkinson's disease (PD) pathogenesis. This work aims to further elucidate the regulatory networks of SNHG1 involved in PD. Methods: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-hydrochlo...
1-Metil-4-fenilpiridinio/toxicidad,
Fosfohidrolasa PTEN/metabolismo,
Enfermedad de Parkinson/metabolismo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
ARN Largo no Codificante/metabolismo,
Serina-Treonina Quinasas TOR/metabolismo,
Enfermedad de Parkinson/genética,
ARN Largo no Codificante/genética,
Apoptosis,
Western Blotting,
Células Cultivadas,
Modelos Animales de Enfermedad,
Regulación de la Expresión Génica,
Ratones Endogámicos C57BL,
MicroARNs,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Transducción de Señal,
Transfección
Montelukast sodium is an effective and well-tolerated anti-asthmatic drug. Long non-coding RNAs (lncRNAs) are involved in the treatment of asthma. Therefore, this study aimed to investigate the effect of montelukast sodium on children with cough-variant asthma (CVA) and the role of lncRNA prostate cancer...
Acetatos/uso terapéutico,
Antiasmáticos/uso terapéutico,
Asma/sangre,
Asma/tratamiento farmacológico,
Tos/sangre,
Tos/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Ratones Endogámicos BALB C,
Sustancias Protectoras/uso terapéutico,
Quinolinas/uso terapéutico,
ARN Largo no Codificante/metabolismo
Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an aberrant activation of immune cells partly due to the dysfunction of cytokines such as type I interferons (IFNs). Long non-coding RNA MALAT1 has been found to play a pathogenic role in SLE; however, the underlying mechanisms a...
BACKGROUND: Osteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients' daily life. It was reported that non-coding RNAs play vital roles in OA. However, the regulation mechanism of ncRNA in OA pathogenes...
Apoptosis/fisiología,
Autofagia/fisiología,
MicroARNs/metabolismo,
Osteoartritis/metabolismo,
ARN Largo no Codificante/metabolismo,
Ubiquitina-Proteína Ligasas/metabolismo,
Apoptosis/genética,
Autofagia/genética,
MicroARNs/genética,
Osteoartritis/genética,
ARN Largo no Codificante/genética,
Ubiquitina-Proteína Ligasas/genética,
Western Blotting,
Proliferación Celular,
Regulación hacia Abajo,
Ensayo de Inmunoadsorción Enzimática,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación hacia Arriba
BACKGROUND: Previous studies have shown that long noncoding RNA (IncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this IncRNA in gastric cancer remains largely unknown. The present study aimed to investigate the effect of LINC0048...
MicroARNs/metabolismo,
Proteína Quinasa 1 Activada por Mitógenos/metabolismo,
ARN Largo no Codificante/metabolismo,
Neoplasias Gástricas/metabolismo,
Carcinogénesis/metabolismo,
Línea Celular Tumoral/metabolismo,
Células Epiteliales/metabolismo,
Luciferasas/metabolismo,
MicroARNs/genética,
ARN Largo no Codificante/genética,
Neoplasias Gástricas/genética,
Apoptosis,
Movimiento Celular,
Supervivencia Celular,
Regulación Neoplásica de la Expresión Génica,
Ratones Endogámicos BALB C,
Ensayos Antitumor por Modelo de Xenoinjerto
