LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro

Farfán, Nicole; Sanhueza, Nicole; Briones, Macarena; Burzio, Luis O; Burzio, Verónica A.

Biol. Res; 54 (), 2021

BACKGROUND: The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, apoptosis and invasiveness reduction in tumor but not normal cells. One of these tra...

MicroARNs/genética, ARN Largo no Codificante/genética, Línea Celular Tumoral, Proliferación Celular, Regulación Neoplásica de la Expresión Génica, ARN sin Sentido/genética, ARN Mitocondrial/genética

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Effect of fasudil on experimental autoimmune neuritis and its mechanisms of action

Zhao, Yanyin; Liu, Bingyou; Wang, Yi; Xiao, Baoguo.

Braz. j. med. biol. res; 53 (1), 2020

This study aimed to investigate the therapeutic effect of fasudil on treating experimental autoimmune neuritis (EAN). Twenty-four EAN mice were randomly assigned to fasudil treatment (Fasudil group) or saline treatment (EAN model group) for 28 days. Clinical symptom score was evaluated every other day; i...

Interferón gamma/sangre, Interleucinas/sangre, Ratones Endogámicos C57BL, Neuritis Autoinmune Experimental/sangre, Neuritis Autoinmune Experimental/tratamiento farmacológico, ARN Mitocondrial, Reacción en Cadena en Tiempo Real de la Polimerasa, Nervio Ciático/efectos de los fármacos, Nervio Ciático/metabolismo, Linfocitos T Colaboradores-Inductores/efectos de los fármacos, Factores de Tiempo

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RNA editing analysis of ATP synthase genes in the cotton cytoplasmic male sterile line H276A

Kong, Xiangjun; Liu, Dongmei; Zheng, Jie; Khan, Aziz; Li, Bin; Diao, Yong; Zhou, Ruiyang.

Biol. Res; 52 (), 2019

BACKGROUND: Pollen development is an energy-consuming process that particularly occurs during meiosis. Low levels of adenosine triphosphate (ATP) may cause cell death, resulting in CMS (cytoplasmic male sterility). DNA sequence differences in ATP synthase genes have been revealed between the N- and S-cyt...

Adenosina Trifosfatasas/genética, Membrana Celular/genética, Gossypium/enzimología, Infertilidad Vegetal/genética, Edición de ARN, Citoplasma/metabolismo, ADN Mitocondrial/genética, Regulación de la Expresión Génica de las Plantas/genética, Gossypium/genética, ARN Mitocondrial/genética, Reacción en Cadena de la Polimerasa

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