Abstract Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interfer...
SUMMARY OBJECTIVE The recent development of direct-acting antiviral agents (DAAs) has dramatically changed the treatment of chronic hepatitis C, and interferon-based regimes have become a poor treatment choice in clinical practice. Today DAAs offer shorter, well-tolerated, highly effective curative the...
Anilidas/uso terapéutico,
Antivirales/uso terapéutico,
Carbamatos/uso terapéutico,
Quimioterapia Combinada,
Genotipo,
Hepacivirus/efectos de los fármacos,
Hepacivirus/genética,
Hepatitis C Crónica/tratamiento farmacológico,
Hepatitis C Crónica/virología,
Fallo Renal Crónico/virología,
Compuestos Macrocíclicos/uso terapéutico,
Persona de Mediana Edad,
ARN Viral/sangre,
Ribavirina/uso terapéutico,
Ritonavir/uso terapéutico,
Estadísticas no Paramétricas,
Sulfonamidas/uso terapéutico,
Respuesta Virológica Sostenida,
Factores de Tiempo,
Resultado del Tratamiento,
Uracilo/análogos & derivados,
Uracilo/uso terapéutico
Abstract By decreasing the pre-seroconversion window period, nucleic acid testing (NAT) has improved the safety of blood products and reduced the risk of transfusion-transmitted infections. Between 2011 and 2017, NAT determinations for approximately 898,202 donations were performed at Fundação Pró-San...
Abstract INTRODUCTION Solid-organ transplant recipients are at risk of hepatitis E virus (HEV) infection. We analyzed the seroprevalence/risk factors of HEV in Croatian liver transplant recipients. METHODS Two hundred forty-two serum samples were tested for HEV immunoglobuline IgG/IgM and HEV RNA. So...
Croacia/epidemiología,
Estudios Transversales,
Anticuerpos Antihepatitis/genética,
Hepatitis E/epidemiología,
Hepatitis E/inmunología,
Virus de la Hepatitis E/inmunología,
Inmunoglobulina G/sangre,
Inmunoglobulina M/sangre,
Trasplante de Hígado/efectos adversos,
Persona de Mediana Edad,
ARN Viral/sangre,
Factores de Riesgo,
Estudios Seroepidemiológicos,
Factores Socioeconómicos
Abstract INTRODUCTION We evaluated the anti-hepatitis E virus (HEV) antibody prevalence and HEV-RNA in archived serum samples of non-A-C hepatitis, or suspected cases of HEV infection from the Eastern Brazilian Amazon from 1993 to 2014. METHODS Serum samples (n = 318) were tested using ELISA and immu...
Brasil,
Ensayo de Inmunoadsorción Enzimática,
Anticuerpos Antihepatitis/sangre,
Hepatitis E/diagnóstico,
Hepatitis E/epidemiología,
Virus de la Hepatitis E/inmunología,
Immunoblotting,
Inmunoglobulina G/sangre,
Inmunoglobulina M/sangre,
Prevalencia,
ARN Viral/sangre,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Estudios Retrospectivos,
Estudios Seroepidemiológicos
Abstract INTRODUCTION: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) have identical transmission routes, explaining the high prevalence of coinfections. The main aim of this study was to detect fluctuations in serological HCV levels in HIV patients. METHODS: We analyzed samples of 14...
Recuento de Linfocito CD4,
Coinfección,
Genotipo,
Infecciones por VIH/complicaciones,
Hepacivirus/genética,
Hepacivirus/inmunología,
Hepatitis C/diagnóstico,
Anticuerpos contra la Hepatitis C/sangre,
Persona de Mediana Edad,
ARN Viral/sangre,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Carga Viral,
Hepatitis C/complicaciones
Abstract INTRODUCTION The prevalence, public health impact, and epidemiological characteristics of hepatitis E virus (HEV) are poorly understood in Brazil. METHODS Serum samples from 535 individuals from three rural Afro-descendant communities located in eastern Brazilian Amazon were collected in Oct...
Población Negra,
Brasil/epidemiología,
Estudios Transversales,
Anticuerpos Antihepatitis/sangre,
Hepatitis E/diagnóstico,
Hepatitis E/epidemiología,
Virus de la Hepatitis E/inmunología,
Inmunoglobulina G/sangre,
Inmunoglobulina M/sangre,
Persona de Mediana Edad,
Prevalencia,
ARN Viral/sangre,
Población Rural,
Estudios Seroepidemiológicos
Andrade, Elisabete;
Rocha, Daniele;
Fontana-Maurell, Marcela;
Costa, Elaine;
Ribeiro, Marisa;
de Godoy, Daniela Tupy;
Ferreira, Antonio G P;
Tanuri, Amilcar;
Alvarez, Patrícia;
Brindeiro, Rodrigo.
ABSTRACT The Brazilian Public Health Service provides freely αPEG-IFN to treat patients infected with HCV. The primary goal of HCV therapy is the long-term elimination of HCV from the blood to reduce the risk of HCV associated complications and death. Patient viremia affects the treatment duration a...
Antivirales/uso terapéutico,
Brasil,
Genotipo,
Técnicas de Genotipaje,
Hepacivirus/genética,
Hepacivirus/aislamiento & purificación,
Hepatitis C/sangre,
Hepatitis C/tratamiento farmacológico,
Hepatitis C/virología,
Interferón-alfa/uso terapéutico,
Polietilenglicoles/uso terapéutico,
Estudios Prospectivos,
ARN Viral/sangre,
ARN Viral/genética,
ARN Viral/aislamiento & purificación,
Reacción en Cadena en Tiempo Real de la Polimerasa/métodos,
Proteínas Recombinantes/uso terapéutico,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Carga Viral/métodos,
Viremia
Abstract Brazil is a non-endemic country for hepatitis E virus (HEV) infection with seroprevalence from 1% to 4% in blood donors and the general population. However, data on seroprevalence of HEV in the country are still limited. This study evaluated the prevalence of past or present HEV infection in a g...
Donantes de Sangre/estadística & datos numéricos,
Brasil/epidemiología,
Anticuerpos Antihepatitis/sangre,
Hepatitis E/diagnóstico,
Hepatitis E/epidemiología,
Virus de la Hepatitis E/inmunología,
Inmunoglobulina G/sangre,
Inmunoglobulina M/sangre,
Prevalencia,
ARN Viral/sangre,
Estudios Seroepidemiológicos
Costi, Cintia;
Grandi, Tarciana;
Halon, Maria Laura;
Silva, Márcia Susana Nunes;
Silva, Cláudia Maria Dornelles da;
Gregianini, Tatiana Schäffer;
Possuelo, Lia Gonçalves;
Jarczewski, Carla Adriane;
Niel, Christian;
Rossetti, Maria Lucia Rosa.
BACKGROUND Porto Alegre is the Brazilian state capital with second highest incidence of tuberculosis (TB) and the highest proportion of people infected with human immunodeficiency virus (HIV) among patients with TB. Hepatitis C virus (HCV) infection increases the risk of anti-TB drug-induced hepatotoxic...
Brasil/epidemiología,
Coinfección/diagnóstico,
Coinfección/epidemiología,
Anticuerpos Anti-VIH/sangre,
Infecciones por VIH/diagnóstico,
Infecciones por VIH/epidemiología,
Hepatitis C/diagnóstico,
Tuberculosis/epidemiología,
Tuberculosis/diagnóstico,
Reacción en Cadena de la Polimerasa,
ARN Viral/sangre
