Evaluation of the bioequivalence of two formulations containing the combination of 400 mg of acetaminophen (paracetamol), 4 mg of phenylephrine and 4 mg of chlorpheniramine in capsules: open-label, three-way crossover study, partially replicated in healthy volunteers of both sexes
Braz. J. Pharm. Sci. (Online); 56 (), 2020
This study was carried out in order to compare the relative bioavailability of two different formulations containing 400 mg of acetaminophen + 4 mg of phenylephrine hydrochloride + 4 mg of chlorpheniramine maleate, Test formulation (Cimegripe®) and Reference formulation (Resfenol®) in 84 healthy volunt...
Acetaminofén/análisis, Fenilefrina/análisis, Clorfeniramina/análisis, Cápsulas/clasificación, Disponibilidad Biológica, Espectrometría de Masas/métodos, Absorción/efectos de los fármacos, Dosis Única, Espectrometría de Masas en Tándem/métodos, Estudios Cruzados, Ayuno/efectos adversos, 34628, Voluntarios Sanos/clasificación