Results: 2

Convergent synthesis of new N -substituted 2-{[5-(1H -indol-3-ylmethyl)-1, 3, 4-oxadiazol-2-yl]sulfanyl}acetamides as suitable therapeutic agents

Rubab, Kaniz; Abbasi, Muhammad Athar; Aziz-ur-Rehman; Siddiqui, Sabahat Zahra; Ashraf, Muhammad; Shaukat, Ayesha; Ahmad, Irshad; Lodhi, Muhammad Arif; Khan, Farman Ali; Shahid, Muhammad; Akhtar, Muhammad Nadeem.

Braz. j. pharm. sci; 51 (4), 2015

abstract A series of N-substituted 2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides (8a-w) was synthesized in three steps. The first step involved the sequential conversion of 2-(1H-indol-3-yl)acetic acid (1) to ester (2) followed by hydrazide (3) formation and finally cyclization in ...

Acetamidas/análisis, Ácido Hidroxiindolacético/análisis, Ensayo de Actividad Hemolítica de Complemento/clasificación, Glicósido Hidrolasas/farmacocinética, Butirilcolinesterasa/análisis, Lipooxigenasas/farmacocinética

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2-Phenitidine derivatives as suitable inhibitors of butyrylcholinesterase

Abbasi, Muhammad Athar; Aziz-ur-Rehman; Qureshi, Muhammad Zahid; Khan, Farhan Mehmood; Khan, Khalid Mohmmed; Ashraf, Muhammad; Afzal, Iftikhar.

Braz. j. pharm. sci; 49 (1), 2013

This manuscript reports the synthesis of a series of N-substituted derivatives of 2-phenitidine. First, the reaction of 2-phenitidine (1) with benzene sulfonyl chloride (2) yielded N-(2-ethoxyphenyl) benzenesulfonamide (3), which further on treatment with sodium hydride and alkyl halides (4a-g) furnished...

Fenetidina/análisis, Butirilcolinesterasa/análisis, Sulfonamidas/análisis, Acetamidas/análisis

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