LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Anticholinesterase activity of β-carboline-1, 3, 5-triazine hybrids

Baréa, Paula; Barbosa, Valéria Aquilino; Yamazaki, Diego Alberto dos Santos; Gomes, Carla Maria Beraldi; Novello, Claudio R; Costa, Willian Ferreira da; Gauze, Gisele de Freitas; Sarragiotto, Maria Helena.

Braz. J. Pharm. Sci. (Online); 58 (), 2022

Abstract The β-carboline-1,3,5-triazine hydrochlorides 8-13 were evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The analysed compounds were selective to BuChE, with IC50 values in the range from 1.0-18.8 µM being obtained. The N-{2-[(4,6-dihydrazinyl-1,3,5-tr...

Butirilcolinesterasa/farmacología, Acetilcolinesterasa/farmacología, Butiriltiocolina/efectos adversos, Carbolinas/agonistas, Dolor, Inhibidores de la Colinesterasa/administración & dosificación, Simulación del Acoplamiento Molecular/instrumentación, Técnicas In Vitro/métodos, Triazinas/efectos adversos

Fulltext

Exposição ambiental/ocupacional aos agrotóxicos em gestantes residentes em um município rural

Objective: The study’s goal has been to analyze if environmental or occupational exposure to pesticides can produce changes in pregnant women living in a countryside municipality. Methods: The participants of this study were twenty-three pregnant women, who both answered a questionnaire and donated bio...