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Improvement of physicochemical parameters of acyclovir using cocrystallization approach

Savjani, Jignasa Ketan; Pathak, Chirag.
Braz. j. pharm. sci; 52 (4), 2016
ABSTRACT Acyclovir is an antiviral drug having potent activity against the virus of herpes family and varicella zoster. Unfortunately, drug suffers very poor oral bioavailability (15-30%). The main objective of present study was to develop acyclovir cocrystals with improved solubility which may result in...
Aciclovir/análisis, 51840/clasificación, Disolución, Solubilidad, Solventes/uso terapéutico
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Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon

Saxena, Ankita; Tewari, Gulab; Saraf, Shubhini Awasthi.
Braz. j. pharm. sci; 47 (4), 2011
Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl me...
Protectores Bucales/clasificación, Protectores Bucales/clasificación, Aciclovir/análisis, Aciclovir/análisis, Liberación de Fármacos, Liberación de Fármacos, Administración Oral, Protectores Bucales/clasificación, Administración Oral, Aciclovir/análisis, Liberación de Fármacos, Administración Oral
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Antivirais
Antivirals

Brik, Decio.
Arq. bras. oftalmol; 56 (6), 1993
Doenças causadas por vírus representam dificuldades terapêuticas. O conjunto de medicamentos antivirais disponíveis é ainda relativamente pequeno, mas tem crescido nos últimos anos em razäo de enormes investimentos materiais e de talentos: a síndrome da imunodeficiência adquirida é, certamente,...
Antivirales/análisis, Idoxuridina/análisis, Aciclovir/análisis, Vidarabina/análisis, Zidovudina/análisis, Didanosina/análisis, Antivirales/efectos adversos, Antivirales/farmacología